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Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis

PURPOSE: To evaluate the association of serum levels of adipokines and cytokines with psoriasis. MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in ser...

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Autores principales: Bai, Fan, Zheng, Wen, Dong, Yan, Wang, Juan, Garstka, Malgorzata A., Li, Ruilian, An, Jingang, Ma, Huiqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787437/
https://www.ncbi.nlm.nih.gov/pubmed/29416693
http://dx.doi.org/10.18632/oncotarget.22260
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author Bai, Fan
Zheng, Wen
Dong, Yan
Wang, Juan
Garstka, Malgorzata A.
Li, Ruilian
An, Jingang
Ma, Huiqun
author_facet Bai, Fan
Zheng, Wen
Dong, Yan
Wang, Juan
Garstka, Malgorzata A.
Li, Ruilian
An, Jingang
Ma, Huiqun
author_sort Bai, Fan
collection PubMed
description PURPOSE: To evaluate the association of serum levels of adipokines and cytokines with psoriasis. MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in serum marker levels between patients and controls were pooled as standardized mean differences (SMDs) with 95% confidence interval to combine the effect estimations. We also conducted stratified analysis, meta-regression analysis and sensitivity analysis. RESULTS: Sixty-three studies containing 2876 psoriasis patients and 2237 healthy controls were included in this meta-analysis. The pooled serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen and C3 were higher in psoriasis patients compared with healthy controls (all P < 0.05). In contrast, adiponectin levels were lower. Serum levels of IL-1β, IL-4, IL-10, IL-12, IL-17, IL-21, IL-23, visfatin and omentin were not significantly different between psoriasis patients and controls (all P > 0.05). However, increased serum levels of IL-17 correlated with psoriasis in men. For other biomarkers, age, gender and psoriasis area and severity index did not explain the differences in effect size between the studies. CONCLUSIONS: Serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen, complement 3, and adiponectin correlate with psoriasis and can be used as potential biomarkers for psoriasis and response to the treatment. Future studies are needed to identify additional players involved in the pathogenesis of psoriasis and to fully decipher the underlying mechanism.
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spelling pubmed-57874372018-02-07 Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis Bai, Fan Zheng, Wen Dong, Yan Wang, Juan Garstka, Malgorzata A. Li, Ruilian An, Jingang Ma, Huiqun Oncotarget Meta-Analysis PURPOSE: To evaluate the association of serum levels of adipokines and cytokines with psoriasis. MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in serum marker levels between patients and controls were pooled as standardized mean differences (SMDs) with 95% confidence interval to combine the effect estimations. We also conducted stratified analysis, meta-regression analysis and sensitivity analysis. RESULTS: Sixty-three studies containing 2876 psoriasis patients and 2237 healthy controls were included in this meta-analysis. The pooled serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen and C3 were higher in psoriasis patients compared with healthy controls (all P < 0.05). In contrast, adiponectin levels were lower. Serum levels of IL-1β, IL-4, IL-10, IL-12, IL-17, IL-21, IL-23, visfatin and omentin were not significantly different between psoriasis patients and controls (all P > 0.05). However, increased serum levels of IL-17 correlated with psoriasis in men. For other biomarkers, age, gender and psoriasis area and severity index did not explain the differences in effect size between the studies. CONCLUSIONS: Serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen, complement 3, and adiponectin correlate with psoriasis and can be used as potential biomarkers for psoriasis and response to the treatment. Future studies are needed to identify additional players involved in the pathogenesis of psoriasis and to fully decipher the underlying mechanism. Impact Journals LLC 2017-11-01 /pmc/articles/PMC5787437/ /pubmed/29416693 http://dx.doi.org/10.18632/oncotarget.22260 Text en Copyright: © 2018 Bai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Bai, Fan
Zheng, Wen
Dong, Yan
Wang, Juan
Garstka, Malgorzata A.
Li, Ruilian
An, Jingang
Ma, Huiqun
Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title_full Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title_fullStr Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title_full_unstemmed Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title_short Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
title_sort serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787437/
https://www.ncbi.nlm.nih.gov/pubmed/29416693
http://dx.doi.org/10.18632/oncotarget.22260
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