3D modeling of cancer stem cell niche

Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models...

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Detalles Bibliográficos
Autores principales: He, Jun, Xiong, Li, Li, Qinglong, Lin, Liangwu, Miao, Xiongying, Yan, Shichao, Hong, Zhangyong, Yang, Leping, Wen, Yu, Deng, Xiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787442/
https://www.ncbi.nlm.nih.gov/pubmed/29416698
http://dx.doi.org/10.18632/oncotarget.19847
Descripción
Sumario:Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.

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