3D modeling of cancer stem cell niche

Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Jun, Xiong, Li, Li, Qinglong, Lin, Liangwu, Miao, Xiongying, Yan, Shichao, Hong, Zhangyong, Yang, Leping, Wen, Yu, Deng, Xiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787442/
https://www.ncbi.nlm.nih.gov/pubmed/29416698
http://dx.doi.org/10.18632/oncotarget.19847
_version_ 1783295929655230464
author He, Jun
Xiong, Li
Li, Qinglong
Lin, Liangwu
Miao, Xiongying
Yan, Shichao
Hong, Zhangyong
Yang, Leping
Wen, Yu
Deng, Xiyun
author_facet He, Jun
Xiong, Li
Li, Qinglong
Lin, Liangwu
Miao, Xiongying
Yan, Shichao
Hong, Zhangyong
Yang, Leping
Wen, Yu
Deng, Xiyun
author_sort He, Jun
collection PubMed
description Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.
format Online
Article
Text
id pubmed-5787442
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-57874422018-02-07 3D modeling of cancer stem cell niche He, Jun Xiong, Li Li, Qinglong Lin, Liangwu Miao, Xiongying Yan, Shichao Hong, Zhangyong Yang, Leping Wen, Yu Deng, Xiyun Oncotarget Review Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites. Impact Journals LLC 2017-08-03 /pmc/articles/PMC5787442/ /pubmed/29416698 http://dx.doi.org/10.18632/oncotarget.19847 Text en Copyright: © 2018 He et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
He, Jun
Xiong, Li
Li, Qinglong
Lin, Liangwu
Miao, Xiongying
Yan, Shichao
Hong, Zhangyong
Yang, Leping
Wen, Yu
Deng, Xiyun
3D modeling of cancer stem cell niche
title 3D modeling of cancer stem cell niche
title_full 3D modeling of cancer stem cell niche
title_fullStr 3D modeling of cancer stem cell niche
title_full_unstemmed 3D modeling of cancer stem cell niche
title_short 3D modeling of cancer stem cell niche
title_sort 3d modeling of cancer stem cell niche
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787442/
https://www.ncbi.nlm.nih.gov/pubmed/29416698
http://dx.doi.org/10.18632/oncotarget.19847
work_keys_str_mv AT hejun 3dmodelingofcancerstemcellniche
AT xiongli 3dmodelingofcancerstemcellniche
AT liqinglong 3dmodelingofcancerstemcellniche
AT linliangwu 3dmodelingofcancerstemcellniche
AT miaoxiongying 3dmodelingofcancerstemcellniche
AT yanshichao 3dmodelingofcancerstemcellniche
AT hongzhangyong 3dmodelingofcancerstemcellniche
AT yangleping 3dmodelingofcancerstemcellniche
AT wenyu 3dmodelingofcancerstemcellniche
AT dengxiyun 3dmodelingofcancerstemcellniche

Ejemplares similares