Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Here we present an innovative computational-based drug discovery strategy, coupled with machine-based learning and functional assessment, for the rational design of novel small molecule inhibitors of the lipogenic enzyme stearoyl-CoA desaturase 1 (SCD1). Our methods resulted in the discovery of seve...

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Detalles Bibliográficos
Autores principales: von Roemeling, Christina A., Caulfield, Thomas R., Marlow, Laura, Bok, Ilah, Wen, Jiang, Miller, James L., Hughes, Robert, Hazlehurst, Lori, Pinkerton, Anthony B., Radisky, Derek C., Tun, Han W., Kim, Yon Son Betty, Lane, Amy L., Copland, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787466/
https://www.ncbi.nlm.nih.gov/pubmed/29416592
http://dx.doi.org/10.18632/oncotarget.21545

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