Cargando…

Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma

Anal squamous cell carcinomas (ASCC) are rare tumours in humans. The etiological role of HPV infection is now well established but little is known about the molecular landscape and signalling pathways involved in the pathogenesis of this cancer. Here we report the results from a whole exome sequenci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cacheux, Wulfran, Dangles-Marie, Virginie, Rouleau, Etienne, Lazartigues, Julien, Girard, Elodie, Briaux, Adrien, Mariani, Pascale, Richon, Sophie, Vacher, Sophie, Buecher, Bruno, Richard-Molard, Marion, Jeannot, Emmanuelle, Servant, Nicolas, Farkhondeh, Fereshteh, Mariani, Odette, Rio-Frio, Thomas, Roman-Roman, Sergio, Mitry, Emmanuel, Bieche, Ivan, Lièvre, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787481/ https://www.ncbi.nlm.nih.gov/pubmed/29416628 http://dx.doi.org/10.18632/oncotarget.23066

Ejemplares similares

Array comparative genomic hybridization identifies high level of PI3K/Akt/mTOR pathway alterations in anal cancer recurrences
por: Cacheux, Wulfran, et al.
Publicado: (2018)

Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection
por: Cacheux, Wulfran, et al.
Publicado: (2016)

Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy
por: Gauthé, Mathieu, et al.
Publicado: (2018)

Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas
por: Morel, Adeline, et al.
Publicado: (2019)

Prognostic Value of Fusobacterium nucleatum after Abdominoperineal Resection for Anal Squamous Cell Carcinoma
por: Hilmi, Marc, et al.
Publicado: (2022)

Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma
por: Tsantoulis, Petros, et al.
Publicado: (2019)

Correction: Protein biomarkers predictive for response to anti-EGFR treatment in RAS wild-type metastatic colorectal carcinoma
por: Lièvre, Astrid, et al.
Publicado: (2018)

Protein biomarkers predictive for response to anti-EGFR treatment in RAS wild-type metastatic colorectal carcinoma
por: Lièvre, Astrid, et al.
Publicado: (2017)

Vasculature analysis of patient derived tumor xenografts using species-specific PCR assays: evidence of tumor endothelial cells and atypical VEGFA-VEGFR1/2 signalings
por: Bieche, Ivan, et al.
Publicado: (2014)

Spontaneous mouse lymphoma in patient-derived tumor xenografts: The importance of systematic analysis of xenografted human tumor tissues in preclinical efficacy trials
por: Chateau-Joubert, Sophie, et al.
Publicado: (2021)

Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site
por: Kamal, Maud, et al.
Publicado: (2020)

Correction to: Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site
por: Kamal, Maud, et al.
Publicado: (2023)

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways
por: Laé, Marick, et al.
Publicado: (2016)

Clinical value of R-spondins in triple-negative and metaplastic breast cancers
por: Coussy, F, et al.
Publicado: (2017)

Arpin downregulation in breast cancer is associated with poor prognosis
por: Lomakina, Maria E, et al.
Publicado: (2016)

High Positive Correlations between ANRIL and p16-CDKN2A/p15-CDKN2B/p14-ARF Gene Cluster Overexpression in Multi-Tumor Types Suggest Deregulated Activation of an ANRIL–ARF Bidirectional Promoter
por: Drak Alsibai, Kinan, et al.
Publicado: (2019)

Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells
por: Vivet-Noguer, Raquel, et al.
Publicado: (2022)

A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation
por: Weiswald, L-B, et al.
Publicado: (2013)

Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma
por: Mainguené, Juliette, et al.
Publicado: (2022)

MMP2 as an independent prognostic stratifier in oral cavity cancers
por: Hoffmann, Caroline, et al.
Publicado: (2020)

ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels
por: Rondeau, S, et al.
Publicado: (2015)

In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy
por: Weiswald, Louis-Bastien, et al.
Publicado: (2010)

Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients
por: Neuzillet, Cindy, et al.
Publicado: (2021)

Patient Derived Xenografts (PDX) Models as an Avatar to Assess Personalized Therapy Options in Uveal Melanoma: A Feasibility Study
por: Nemati, Fariba, et al.
Publicado: (2023)

PIK3R1 underexpression is an independent prognostic marker in breast cancer
por: Cizkova, Magdalena, et al.
Publicado: (2013)

Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial
por: Le Tourneau, C, et al.
Publicado: (2014)

The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors
por: Nordor, Akpéli V., et al.
Publicado: (2017)

Hallmarks of Aging in the Liver
por: Hunt, Nicholas J., et al.
Publicado: (2019)

The Cellular Prion Protein and the Hallmarks of Cancer
por: Mouillet-Richard, Sophie, et al.
Publicado: (2021)

The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis
por: Lallemand, François, et al.
Publicado: (2020)

Radiographic technical quality of root canal treatment performed ex vivo by dental students at Valencia University Medical and Dental School, Spain
por: Román-Richon, Sophie, et al.
Publicado: (2014)

MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?
por: Cizeron-Clairac, Geraldine, et al.
Publicado: (2015)

Protein kinase D1 regulates ERα-positive breast cancer cell growth response to 17β-estradiol and contributes to poor prognosis in patients
por: Karam, Manale, et al.
Publicado: (2014)

Differential Expression of Genes Involved in Metabolism and Immune Response in Diffuse and Intestinal Gastric Cancers, a Pilot Ptudy
por: Perrot-Applanat, Martine, et al.
Publicado: (2022)

MRI-Based Radiomics Input for Prediction of 2-Year Disease Recurrence in Anal Squamous Cell Carcinoma
por: Giraud, Nicolas, et al.
Publicado: (2021)

Hallmarks of cancer and hallmarks of aging
por: Blagosklonny, Mikhail V.
Publicado: (2022)

Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers
por: Renault, Anne-Laure, et al.
Publicado: (2018)

NF-kappa B genes have a major role in Inflammatory Breast Cancer
por: Lerebours, Florence, et al.
Publicado: (2008)

HORMAD1 overexpression predicts response to anthracycline–cyclophosphamide and survival in triple‐negative breast cancers
por: El‐Botty, Rania, et al.
Publicado: (2023)

Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly
por: Attieh, Youmna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_oo40g8p3bkoh7ljclk83r55n2h