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Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum
Chronic inflammation is one of the underlying risks associated with thyroid cancer. We ascertained the association between commonly measured serum biomarkers of inflammation and the risk of thyroid cancer in Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. 226,212 subjects had baseline...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787509/ https://www.ncbi.nlm.nih.gov/pubmed/29416653 http://dx.doi.org/10.18632/oncotarget.22891 |
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author | Ghoshal, Arunangshu Garmo, Hans Arthur, Rhonda Carroll, Paul Holmberg, Lars Hammar, Niklas Jungner, Ingmar Malmström, Håkan Lambe, Mats Walldius, Göran Van Hemelrijck, Mieke |
author_facet | Ghoshal, Arunangshu Garmo, Hans Arthur, Rhonda Carroll, Paul Holmberg, Lars Hammar, Niklas Jungner, Ingmar Malmström, Håkan Lambe, Mats Walldius, Göran Van Hemelrijck, Mieke |
author_sort | Ghoshal, Arunangshu |
collection | PubMed |
description | Chronic inflammation is one of the underlying risks associated with thyroid cancer. We ascertained the association between commonly measured serum biomarkers of inflammation and the risk of thyroid cancer in Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. 226,212 subjects had baseline measurements of C-reactive protein, albumin and haptoglobin. Leukocytes were measured in a subgroup of 63,845 subjects. Associations between quartiles and dichotomized values of inflammatory markers and risk of thyroid cancer were analysed using multivariate Cox proportional hazard models. 202 individuals were diagnosed with thyroid cancer during a mean follow-up of 19.6 years. There was a positive association between lower albumin levels and risk of developing thyroid cancer [Hazard Ratio for albumin ≤ 40 g/L: 1.50 (95% Confidence Interval = 1.04–2.16)]. When stratified by a metabolic score, we observed similar association for albumin with higher HR among those with metabolic score ≥ 1, as compared to those with metabolic score of 0 [HR 1.98 (95% CI = 1.11-3.54) vs 1.17 (95% CI = 0.72–1.89)] (P = 0.19). Apart from albumin, none of the serum markers of inflammation studied showed a link with the risk of developing thyroid cancer–suggesting that the role of inflammation may be more complicated and requires assessment of more specialised measurements of inflammation. |
format | Online Article Text |
id | pubmed-5787509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57875092018-02-07 Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum Ghoshal, Arunangshu Garmo, Hans Arthur, Rhonda Carroll, Paul Holmberg, Lars Hammar, Niklas Jungner, Ingmar Malmström, Håkan Lambe, Mats Walldius, Göran Van Hemelrijck, Mieke Oncotarget Research Paper Chronic inflammation is one of the underlying risks associated with thyroid cancer. We ascertained the association between commonly measured serum biomarkers of inflammation and the risk of thyroid cancer in Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. 226,212 subjects had baseline measurements of C-reactive protein, albumin and haptoglobin. Leukocytes were measured in a subgroup of 63,845 subjects. Associations between quartiles and dichotomized values of inflammatory markers and risk of thyroid cancer were analysed using multivariate Cox proportional hazard models. 202 individuals were diagnosed with thyroid cancer during a mean follow-up of 19.6 years. There was a positive association between lower albumin levels and risk of developing thyroid cancer [Hazard Ratio for albumin ≤ 40 g/L: 1.50 (95% Confidence Interval = 1.04–2.16)]. When stratified by a metabolic score, we observed similar association for albumin with higher HR among those with metabolic score ≥ 1, as compared to those with metabolic score of 0 [HR 1.98 (95% CI = 1.11-3.54) vs 1.17 (95% CI = 0.72–1.89)] (P = 0.19). Apart from albumin, none of the serum markers of inflammation studied showed a link with the risk of developing thyroid cancer–suggesting that the role of inflammation may be more complicated and requires assessment of more specialised measurements of inflammation. Impact Journals LLC 2017-12-04 /pmc/articles/PMC5787509/ /pubmed/29416653 http://dx.doi.org/10.18632/oncotarget.22891 Text en Copyright: © 2018 Ghoshal et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ghoshal, Arunangshu Garmo, Hans Arthur, Rhonda Carroll, Paul Holmberg, Lars Hammar, Niklas Jungner, Ingmar Malmström, Håkan Lambe, Mats Walldius, Göran Van Hemelrijck, Mieke Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title | Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title_full | Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title_fullStr | Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title_full_unstemmed | Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title_short | Thyroid cancer risk in the Swedish AMORIS study: the role of inflammatory biomarkers in serum |
title_sort | thyroid cancer risk in the swedish amoris study: the role of inflammatory biomarkers in serum |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787509/ https://www.ncbi.nlm.nih.gov/pubmed/29416653 http://dx.doi.org/10.18632/oncotarget.22891 |
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