Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients

A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C a...

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Autores principales: Du, Lehui, Yu, Wei, Dai, Xiangkun, Zhao, Nana, Huang, Xiang, Tong, Fang, Liu, Fang, Huang, Yurong, Ju, Zhongjian, Yang, Wei, Cong, Xiaohu, Xie, Chuanbin, Liu, Xiaoliang, Liang, Lanqing, Han, Yanan, Qu, Baolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787526/
https://www.ncbi.nlm.nih.gov/pubmed/29416669
http://dx.doi.org/10.18632/oncotarget.22982
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author Du, Lehui
Yu, Wei
Dai, Xiangkun
Zhao, Nana
Huang, Xiang
Tong, Fang
Liu, Fang
Huang, Yurong
Ju, Zhongjian
Yang, Wei
Cong, Xiaohu
Xie, Chuanbin
Liu, Xiaoliang
Liang, Lanqing
Han, Yanan
Qu, Baolin
author_facet Du, Lehui
Yu, Wei
Dai, Xiangkun
Zhao, Nana
Huang, Xiang
Tong, Fang
Liu, Fang
Huang, Yurong
Ju, Zhongjian
Yang, Wei
Cong, Xiaohu
Xie, Chuanbin
Liu, Xiaoliang
Liang, Lanqing
Han, Yanan
Qu, Baolin
author_sort Du, Lehui
collection PubMed
description A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs. CC, adjusted HR = 0.517, 95% CI, 0.285–0.939; adjusted P = 0.030). It is the first time demonstrating that CT/TT genotype of ERCC1 354 was significantly associated with lower RP risk after radio therapy.
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spelling pubmed-57875262018-02-07 Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients Du, Lehui Yu, Wei Dai, Xiangkun Zhao, Nana Huang, Xiang Tong, Fang Liu, Fang Huang, Yurong Ju, Zhongjian Yang, Wei Cong, Xiaohu Xie, Chuanbin Liu, Xiaoliang Liang, Lanqing Han, Yanan Qu, Baolin Oncotarget Research Paper A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs. CC, adjusted HR = 0.517, 95% CI, 0.285–0.939; adjusted P = 0.030). It is the first time demonstrating that CT/TT genotype of ERCC1 354 was significantly associated with lower RP risk after radio therapy. Impact Journals LLC 2017-12-05 /pmc/articles/PMC5787526/ /pubmed/29416669 http://dx.doi.org/10.18632/oncotarget.22982 Text en Copyright: © 2018 Du et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Du, Lehui
Yu, Wei
Dai, Xiangkun
Zhao, Nana
Huang, Xiang
Tong, Fang
Liu, Fang
Huang, Yurong
Ju, Zhongjian
Yang, Wei
Cong, Xiaohu
Xie, Chuanbin
Liu, Xiaoliang
Liang, Lanqing
Han, Yanan
Qu, Baolin
Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title_full Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title_fullStr Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title_full_unstemmed Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title_short Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
title_sort association of dna repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787526/
https://www.ncbi.nlm.nih.gov/pubmed/29416669
http://dx.doi.org/10.18632/oncotarget.22982
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