Cargando…

Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles

INTRODUCTION: Pertussis is re-emerging worldwide, despite effective immunization programs for infants and children. Epidemiological studies show a more limited duration of protection against clinical pertussis in adolescents primed with acellular pertussis (aP) vaccines during infancy than those who...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Lee, Saskia, Hendrikx, Lotte H., Sanders, Elisabeth A. M., Berbers, Guy A. M., Buisman, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787539/
https://www.ncbi.nlm.nih.gov/pubmed/29416544
http://dx.doi.org/10.3389/fimmu.2018.00051
_version_ 1783295952375775232
author van der Lee, Saskia
Hendrikx, Lotte H.
Sanders, Elisabeth A. M.
Berbers, Guy A. M.
Buisman, Anne-Marie
author_facet van der Lee, Saskia
Hendrikx, Lotte H.
Sanders, Elisabeth A. M.
Berbers, Guy A. M.
Buisman, Anne-Marie
author_sort van der Lee, Saskia
collection PubMed
description INTRODUCTION: Pertussis is re-emerging worldwide, despite effective immunization programs for infants and children. Epidemiological studies show a more limited duration of protection against clinical pertussis in adolescents primed with acellular pertussis (aP) vaccines during infancy than those who have been primed with whole-cell pertussis (wP) vaccines. This study aimed to determine whether memory immune responses to aP, diphtheria, and tetanus vaccine antigens following booster vaccinations at 4 and 9 years of age differ between wP- versus aP-primed children. METHODS: In a cross-sectional study, blood was collected of DTwP- or diphtheria, tetanus, and aP (DTaP)-primed children before, 1 month, and 2 years after the preschool DTaP booster administered at 4 years of age (n = 41–63 per time point). In a longitudinal study, blood was sampled of DTwP- or DTaP-primed children before, 1 month, and 1 year after a preadolescent Tdap booster at 9 years of age (n = 79–83 per time point). Pertussis, diphtheria, and tetanus vaccine antigen-specific IgG levels, B-cell and T-cell responses were determined. RESULTS: After the preschool booster vaccination, IgG levels were significantly higher in aP-primed as compared with wP-primed children until 6 years of age. Before the preadolescent Tdap booster vaccination, humoral and cellular immune responses were similar in aP- and wP-primed children. However, the Tdap booster vaccination induced lower vaccine antigen-specific humoral, B-cell, and T-helper 1 (Th1) cell responses resulting in significantly lower Th1/Th2 ratios in aP-primed compared with wP-primed children. CONCLUSION: The memory immune profiles at preadolescent age to all DTaP vaccine antigens are already determined by the wP or aP combination vaccines given in infancy, showing a beneficial Th1-dominated response after wP-priming. These immunological data corroborate epidemiological data showing that DTaP-primed adolescents are less protected against clinical pertussis than DTwP-primed children.
format Online
Article
Text
id pubmed-5787539
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-57875392018-02-07 Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles van der Lee, Saskia Hendrikx, Lotte H. Sanders, Elisabeth A. M. Berbers, Guy A. M. Buisman, Anne-Marie Front Immunol Immunology INTRODUCTION: Pertussis is re-emerging worldwide, despite effective immunization programs for infants and children. Epidemiological studies show a more limited duration of protection against clinical pertussis in adolescents primed with acellular pertussis (aP) vaccines during infancy than those who have been primed with whole-cell pertussis (wP) vaccines. This study aimed to determine whether memory immune responses to aP, diphtheria, and tetanus vaccine antigens following booster vaccinations at 4 and 9 years of age differ between wP- versus aP-primed children. METHODS: In a cross-sectional study, blood was collected of DTwP- or diphtheria, tetanus, and aP (DTaP)-primed children before, 1 month, and 2 years after the preschool DTaP booster administered at 4 years of age (n = 41–63 per time point). In a longitudinal study, blood was sampled of DTwP- or DTaP-primed children before, 1 month, and 1 year after a preadolescent Tdap booster at 9 years of age (n = 79–83 per time point). Pertussis, diphtheria, and tetanus vaccine antigen-specific IgG levels, B-cell and T-cell responses were determined. RESULTS: After the preschool booster vaccination, IgG levels were significantly higher in aP-primed as compared with wP-primed children until 6 years of age. Before the preadolescent Tdap booster vaccination, humoral and cellular immune responses were similar in aP- and wP-primed children. However, the Tdap booster vaccination induced lower vaccine antigen-specific humoral, B-cell, and T-helper 1 (Th1) cell responses resulting in significantly lower Th1/Th2 ratios in aP-primed compared with wP-primed children. CONCLUSION: The memory immune profiles at preadolescent age to all DTaP vaccine antigens are already determined by the wP or aP combination vaccines given in infancy, showing a beneficial Th1-dominated response after wP-priming. These immunological data corroborate epidemiological data showing that DTaP-primed adolescents are less protected against clinical pertussis than DTwP-primed children. Frontiers Media S.A. 2018-01-24 /pmc/articles/PMC5787539/ /pubmed/29416544 http://dx.doi.org/10.3389/fimmu.2018.00051 Text en Copyright © 2018 van der Lee, Hendrikx, Sanders, Berbers and Buisman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
van der Lee, Saskia
Hendrikx, Lotte H.
Sanders, Elisabeth A. M.
Berbers, Guy A. M.
Buisman, Anne-Marie
Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title_full Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title_fullStr Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title_full_unstemmed Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title_short Whole-Cell or Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular Immune Profiles
title_sort whole-cell or acellular pertussis primary immunizations in infancy determines adolescent cellular immune profiles
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787539/
https://www.ncbi.nlm.nih.gov/pubmed/29416544
http://dx.doi.org/10.3389/fimmu.2018.00051
work_keys_str_mv AT vanderleesaskia wholecelloracellularpertussisprimaryimmunizationsininfancydeterminesadolescentcellularimmuneprofiles
AT hendrikxlotteh wholecelloracellularpertussisprimaryimmunizationsininfancydeterminesadolescentcellularimmuneprofiles
AT sanderselisabetham wholecelloracellularpertussisprimaryimmunizationsininfancydeterminesadolescentcellularimmuneprofiles
AT berbersguyam wholecelloracellularpertussisprimaryimmunizationsininfancydeterminesadolescentcellularimmuneprofiles
AT buismanannemarie wholecelloracellularpertussisprimaryimmunizationsininfancydeterminesadolescentcellularimmuneprofiles