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Collective Sensing of β-Cells Generates the Metabolic Code
Major part of a pancreatic islet is composed of β-cells that secrete insulin, a key hormone regulating influx of nutrients into all cells in a vertebrate organism to support nutrition, housekeeping or energy storage. β-cells constantly communicate with each other using both direct, short-range inter...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787558/ https://www.ncbi.nlm.nih.gov/pubmed/29416515 http://dx.doi.org/10.3389/fphys.2018.00031 |
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author | Korošak, Dean Slak Rupnik, Marjan |
author_facet | Korošak, Dean Slak Rupnik, Marjan |
author_sort | Korošak, Dean |
collection | PubMed |
description | Major part of a pancreatic islet is composed of β-cells that secrete insulin, a key hormone regulating influx of nutrients into all cells in a vertebrate organism to support nutrition, housekeeping or energy storage. β-cells constantly communicate with each other using both direct, short-range interactions through gap junctions, and paracrine long-range signaling. However, how these cell interactions shape collective sensing and cell behavior in islets that leads to insulin release is unknown. When stimulated by specific ligands, primarily glucose, β-cells collectively respond with expression of a series of transient Ca(2+) changes on several temporal scales. Here we reanalyze a set of Ca(2+) spike trains recorded in acute rodent pancreatic tissue slice under physiological conditions. We found strongly correlated states of co-spiking cells coexisting with mostly weak pairwise correlations widespread across the islet. Furthermore, the collective Ca(2+) spiking activity in islet shows on-off intermittency with scaling of spiking amplitudes, and stimulus dependent autoassociative memory features. We use a simple spin glass-like model for the functional network of a β-cell collective to describe these findings and argue that Ca(2+) spike trains produced by collective sensing of β-cells constitute part of the islet metabolic code that regulates insulin release and limits the islet size. |
format | Online Article Text |
id | pubmed-5787558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57875582018-02-07 Collective Sensing of β-Cells Generates the Metabolic Code Korošak, Dean Slak Rupnik, Marjan Front Physiol Physiology Major part of a pancreatic islet is composed of β-cells that secrete insulin, a key hormone regulating influx of nutrients into all cells in a vertebrate organism to support nutrition, housekeeping or energy storage. β-cells constantly communicate with each other using both direct, short-range interactions through gap junctions, and paracrine long-range signaling. However, how these cell interactions shape collective sensing and cell behavior in islets that leads to insulin release is unknown. When stimulated by specific ligands, primarily glucose, β-cells collectively respond with expression of a series of transient Ca(2+) changes on several temporal scales. Here we reanalyze a set of Ca(2+) spike trains recorded in acute rodent pancreatic tissue slice under physiological conditions. We found strongly correlated states of co-spiking cells coexisting with mostly weak pairwise correlations widespread across the islet. Furthermore, the collective Ca(2+) spiking activity in islet shows on-off intermittency with scaling of spiking amplitudes, and stimulus dependent autoassociative memory features. We use a simple spin glass-like model for the functional network of a β-cell collective to describe these findings and argue that Ca(2+) spike trains produced by collective sensing of β-cells constitute part of the islet metabolic code that regulates insulin release and limits the islet size. Frontiers Media S.A. 2018-01-24 /pmc/articles/PMC5787558/ /pubmed/29416515 http://dx.doi.org/10.3389/fphys.2018.00031 Text en Copyright © 2018 Korošak and Slak Rupnik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Korošak, Dean Slak Rupnik, Marjan Collective Sensing of β-Cells Generates the Metabolic Code |
title | Collective Sensing of β-Cells Generates the Metabolic Code |
title_full | Collective Sensing of β-Cells Generates the Metabolic Code |
title_fullStr | Collective Sensing of β-Cells Generates the Metabolic Code |
title_full_unstemmed | Collective Sensing of β-Cells Generates the Metabolic Code |
title_short | Collective Sensing of β-Cells Generates the Metabolic Code |
title_sort | collective sensing of β-cells generates the metabolic code |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787558/ https://www.ncbi.nlm.nih.gov/pubmed/29416515 http://dx.doi.org/10.3389/fphys.2018.00031 |
work_keys_str_mv | AT korosakdean collectivesensingofbcellsgeneratesthemetaboliccode AT slakrupnikmarjan collectivesensingofbcellsgeneratesthemetaboliccode |