Two approaches reveal a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation’ with potential in human disease

Imprinted genes are vulnerable to environmental influences during early embryonic development, thereby contributing to the onset of disease in adulthood. Monoallelic methylation at several germline imprints has been reported as DNMT1-dependent. However, which of these two epigenetic attributes, DNMT...

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Detalles Bibliográficos
Autores principales: Martos, Suzanne N, Li, Teng, Ramos, Ramon Bossardi, Lou, Dan, Dai, Hongzheng, Xu, Jin-Chong, Gao, Ganglong, Gao, Yang, Wang, Qinglu, An, Cheng, Zhang, Xueli, Jia, Yankai, Dawson, Valina L, Dawson, Ted M, Ji, Hongkai, Wang, Zhibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787696/
https://www.ncbi.nlm.nih.gov/pubmed/29387450
http://dx.doi.org/10.1038/celldisc.2017.38

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