Cargando…

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus

Calcium (Ca(2+)) is an essential second messenger required for diverse signaling processes in immune cells. Ca(2+) release-activated Ca(2+) (CRAC) channels represent one main Ca(2+) entry pathway into the cell. They are fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Derler, Isabella, Butorac, Carmen, Krizova, Adéla, Stadlbauer, Michael, Muik, Martin, Fahrner, Marc, Frischauf, Irene, Romanin, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787803/ https://www.ncbi.nlm.nih.gov/pubmed/29237734 http://dx.doi.org/10.1074/jbc.M117.812206

Ejemplares similares

Communication between N terminus and loop2 tunes Orai activation
por: Fahrner, Marc, et al.
Publicado: (2018)

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating
por: Bergsmann, Judith, et al.
Publicado: (2011)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
por: Frischauf, Irene, et al.
Publicado: (2011)

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
por: Fahrner, Marc, et al.
Publicado: (2014)

The STIM1/Orai signaling machinery
por: Fahrner, Marc, et al.
Publicado: (2013)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
por: Höglinger, Carmen, et al.
Publicado: (2021)

Critical parameters maintaining authentic CRAC channel hallmarks
por: Krizova, Adéla, et al.
Publicado: (2019)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
por: Tiffner, Adéla, et al.
Publicado: (2020)

Molecular mechanisms of STIM/Orai communication
por: Derler, Isabella, et al.
Publicado: (2016)

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions
por: Allsopp, Rebecca C., et al.
Publicado: (2013)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

Local Cytosolic Ca(2+) Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca(2+) Entry
por: Shen, Wei-Wei, et al.
Publicado: (2011)

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF
por: Yuan, Jimin, et al.
Publicado: (2018)

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines
por: Zheng, Sisi, et al.
Publicado: (2018)

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
por: Stathopulos, Peter B., et al.
Publicado: (2013)

Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function
por: Muik, Martin, et al.
Publicado: (2012)

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells
por: Madl, Josef, et al.
Publicado: (2010)

More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins
por: Berlansky, Sascha, et al.
Publicado: (2021)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
por: Penna, Aubin, et al.
Publicado: (2008)

Regulation of Orai1/STIM1 mediated I(CRAC) by intracellular pH
por: Gavriliouk, D., et al.
Publicado: (2017)

N Terminus Is Key to the Dominant Negative Suppression of Ca(V)2 Calcium Channels: IMPLICATIONS FOR EPISODIC ATAXIA TYPE 2
por: Page, Karen M., et al.
Publicado: (2010)

ATP depletion induces translocation of STIM1 to puncta and formation of STIM1–ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
por: Chvanov, Michael, et al.
Publicado: (2008)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
por: Fahrner, Marc, et al.
Publicado: (2018)

Cell-Cell Contact Formation Governs Ca(2+) Signaling by TRPC4 in the Vascular Endothelium: EVIDENCE FOR A REGULATORY TRPC4-β-CATENIN INTERACTION
por: Graziani, Annarita, et al.
Publicado: (2010)

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation
por: Rathner, Petr, et al.
Publicado: (2021)

Modulation of Voltage- and Ca(2+)-dependent Gating of Ca(V)1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain
por: Singh, Anamika, et al.
Publicado: (2008)

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance : The Medical Research Council Ely Prospective Study 1990–2000
por: Forouhi, Nita G., et al.
Publicado: (2008)

Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase
por: Simone, Simona, et al.
Publicado: (2008)

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
por: Maile, Laura A., et al.
Publicado: (2008)

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
por: Morino, Katsutaro, et al.
Publicado: (2008)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
por: Senokuchi, Takafumi, et al.
Publicado: (2008)

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
por: Wang, Zhong Q., et al.
Publicado: (2008)

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
por: Deng, Jen-Ying, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_kkmijo5si0s41ft2pa38e29ao3