CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus

BACKGROUND: The CRISPR/dCas9 system is a powerful tool to activate the transcription of target genes in eukaryotic or prokaryotic cells, but lacks assays in complex conditions, such as the biosynthesis of secondary metabolites. RESULTS: In this study, to improve the transcription of the heterologous...

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Detalles Bibliográficos
Autores principales: Peng, Ran, Wang, Ye, Feng, Wan-wan, Yue, Xin-jing, Chen, Jiang-he, Hu, Xiao-zhuang, Li, Zhi-feng, Sheng, Duo-hong, Zhang, You-ming, Li, Yue-zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787926/
https://www.ncbi.nlm.nih.gov/pubmed/29378572
http://dx.doi.org/10.1186/s12934-018-0867-1

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