Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization

BACKGROUND: The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific enhancer regions in response to β-estradiol (E2) which unde...

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Detalles Bibliográficos
Autores principales: Kolendowski, Bart, Hassan, Haider, Krstic, Milica, Isovic, Majdina, Thillainadesan, Gobi, Chambers, Ann F., Tuck, Alan B., Torchia, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787930/
https://www.ncbi.nlm.nih.gov/pubmed/29378668
http://dx.doi.org/10.1186/s13072-018-0176-2

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