Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?

Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that i...

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Detalles Bibliográficos
Autores principales: Faria-Urbina, Mariana, Oliveira, Rudolf K.F., Segrera, Sergio A., Lawler, Laurie, Waxman, Aaron B., Systrom, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788103/
https://www.ncbi.nlm.nih.gov/pubmed/29309261
http://dx.doi.org/10.1177/2045893218755325
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author Faria-Urbina, Mariana
Oliveira, Rudolf K.F.
Segrera, Sergio A.
Lawler, Laurie
Waxman, Aaron B.
Systrom, David M.
author_facet Faria-Urbina, Mariana
Oliveira, Rudolf K.F.
Segrera, Sergio A.
Lawler, Laurie
Waxman, Aaron B.
Systrom, David M.
author_sort Faria-Urbina, Mariana
collection PubMed
description Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre-existing skeletal muscle abnormality.
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spelling pubmed-57881032018-02-02 Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car? Faria-Urbina, Mariana Oliveira, Rudolf K.F. Segrera, Sergio A. Lawler, Laurie Waxman, Aaron B. Systrom, David M. Pulm Circ Research Letter Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO(2)max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO(2)). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre-existing skeletal muscle abnormality. SAGE Publications 2018-01-08 /pmc/articles/PMC5788103/ /pubmed/29309261 http://dx.doi.org/10.1177/2045893218755325 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Faria-Urbina, Mariana
Oliveira, Rudolf K.F.
Segrera, Sergio A.
Lawler, Laurie
Waxman, Aaron B.
Systrom, David M.
Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title_full Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title_fullStr Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title_full_unstemmed Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title_short Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
title_sort impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788103/
https://www.ncbi.nlm.nih.gov/pubmed/29309261
http://dx.doi.org/10.1177/2045893218755325
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