Architecture of eukaryotic mRNA 3′-end processing machinery

Newly transcribed eukaryotic precursor messenger RNAs (pre-mRNAs) are processed at their 3’ ends by the ~1-megadalton multiprotein cleavage and polyadenylation factor (CPF). CPF cleaves pre-mRNAs, adds a polyadenylate tail, and triggers transcription termination, but it is unclear how its various en...

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Detalles Bibliográficos
Autores principales: Casañal, Ana, Kumar, Ananthanarayanan, Hill, Chris H., Easter, Ashley D., Emsley, Paul, Degliesposti, Gianluca, Gordiyenko, Yuliya, Santhanam, Balaji, Wolf, Jana, Wiederhold, Katrin, Dornan, Gillian L., Skehel, Mark, Robinson, Carol V., Passmore, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788269/
https://www.ncbi.nlm.nih.gov/pubmed/29074584
http://dx.doi.org/10.1126/science.aao6535

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