Identification of cell cycle-targeting microRNAs through genome-wide screens

By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects wit...

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Autores principales: Hydbring, Per, Wang, Yinan, Bogorad, Roman L., Yin, Hao, Anderson, Daniel G., Li, Cheng, Sicinski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788471/
https://www.ncbi.nlm.nih.gov/pubmed/29099267
http://dx.doi.org/10.1080/15384101.2017.1380132
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author Hydbring, Per
Wang, Yinan
Bogorad, Roman L.
Yin, Hao
Anderson, Daniel G.
Li, Cheng
Sicinski, Piotr
author_facet Hydbring, Per
Wang, Yinan
Bogorad, Roman L.
Yin, Hao
Anderson, Daniel G.
Li, Cheng
Sicinski, Piotr
author_sort Hydbring, Per
collection PubMed
description By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.
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spelling pubmed-57884712018-01-31 Identification of cell cycle-targeting microRNAs through genome-wide screens Hydbring, Per Wang, Yinan Bogorad, Roman L. Yin, Hao Anderson, Daniel G. Li, Cheng Sicinski, Piotr Cell Cycle Extra View By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients. Taylor & Francis 2017-11-14 /pmc/articles/PMC5788471/ /pubmed/29099267 http://dx.doi.org/10.1080/15384101.2017.1380132 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Extra View
Hydbring, Per
Wang, Yinan
Bogorad, Roman L.
Yin, Hao
Anderson, Daniel G.
Li, Cheng
Sicinski, Piotr
Identification of cell cycle-targeting microRNAs through genome-wide screens
title Identification of cell cycle-targeting microRNAs through genome-wide screens
title_full Identification of cell cycle-targeting microRNAs through genome-wide screens
title_fullStr Identification of cell cycle-targeting microRNAs through genome-wide screens
title_full_unstemmed Identification of cell cycle-targeting microRNAs through genome-wide screens
title_short Identification of cell cycle-targeting microRNAs through genome-wide screens
title_sort identification of cell cycle-targeting micrornas through genome-wide screens
topic Extra View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788471/
https://www.ncbi.nlm.nih.gov/pubmed/29099267
http://dx.doi.org/10.1080/15384101.2017.1380132
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