Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4

Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that auto...

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Detalles Bibliográficos
Autores principales: Sakamaki, Jun-Ichi, Ryan, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788487/
https://www.ncbi.nlm.nih.gov/pubmed/28933601
http://dx.doi.org/10.1080/15548627.2017.1364822
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author Sakamaki, Jun-Ichi
Ryan, Kevin M.
author_facet Sakamaki, Jun-Ichi
Ryan, Kevin M.
author_sort Sakamaki, Jun-Ichi
collection PubMed
description Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that autophagy programs are transcriptionally suppressed by the BET family protein BRD4. This repression is alleviated during nutrient deprivation through the AMPK-SIRT1 pathway. Our findings therefore provide new insights into the regulation of autophagy.
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spelling pubmed-57884872018-02-01 Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4 Sakamaki, Jun-Ichi Ryan, Kevin M. Autophagy Autophagic Punctum Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that autophagy programs are transcriptionally suppressed by the BET family protein BRD4. This repression is alleviated during nutrient deprivation through the AMPK-SIRT1 pathway. Our findings therefore provide new insights into the regulation of autophagy. Taylor & Francis 2017-09-21 /pmc/articles/PMC5788487/ /pubmed/28933601 http://dx.doi.org/10.1080/15548627.2017.1364822 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Autophagic Punctum
Sakamaki, Jun-Ichi
Ryan, Kevin M.
Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title_full Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title_fullStr Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title_full_unstemmed Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title_short Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
title_sort transcriptional regulation of autophagy and lysosomal function by bromodomain protein brd4
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788487/
https://www.ncbi.nlm.nih.gov/pubmed/28933601
http://dx.doi.org/10.1080/15548627.2017.1364822
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AT ryankevinm transcriptionalregulationofautophagyandlysosomalfunctionbybromodomainproteinbrd4

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