Cargando…

Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway

Bone is the most common target organ of metastasis of breast cancers. This produces considerable morbidity due to skeletal-related events, and severely reduces the quality of life. Increased osteoclast activity is implicated in breast cancer outgrowth in the bone microenvironment. Our previous obser...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ouyang, Zhengxiao, Guo, Xiaoning, Chen, Xia, Liu, Bo, Zhang, Qiang, Yin, Ziqing, Zhai, Zanjing, Qu, Xinhua, Liu, Xuqiang, Peng, Dan, Shen, Yi, Liu, Tang, Zhang, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788605/ https://www.ncbi.nlm.nih.gov/pubmed/29416737 http://dx.doi.org/10.18632/oncotarget.22930

Ejemplares similares

Correction: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway
por: Ouyang, Zhengxiao, et al.
Publicado: (2019)

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption
por: Liu, Xuqiang, et al.
Publicado: (2017)

The Beneficial Effects of Bisphosphonate-enoxacin on Cortical Bone Mass and Strength in Ovariectomized Rats
por: Liu, Xuqiang, et al.
Publicado: (2017)

Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression
por: ZHAI, ZANJING, et al.
Publicado: (2015)

Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression
por: Zhai, Zanjing, et al.
Publicado: (2019)

The Inhibition of RANKL-Induced Osteoclastogenesis through the Suppression of p38 Signaling Pathway by Naringenin and Attenuation of Titanium-Particle-Induced Osteolysis
por: Wang, Wengang, et al.
Publicado: (2014)

Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro
por: Wang, Chuandong, et al.
Publicado: (2017)

Regulation of NFATc1 in Osteoclast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2014)

Tumor ablation using novel photothermal Na(x)WO(3) nanoparticles against breast cancer osteolytic bone metastasis
por: Jie, Shuo, et al.
Publicado: (2019)

Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation
por: Liu, Qian, et al.
Publicado: (2016)

Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo
por: Chun, Kwang-Hoon, et al.
Publicado: (2020)

Evaluation of White Cell Count and Differential in Synovial Fluid for Diagnosing Infections after Total Hip or Knee Arthroplasty
por: Qu, Xinhua, et al.
Publicado: (2014)

Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1
por: Kim, Kwang-Jin, et al.
Publicado: (2018)

mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1
por: Huynh, HoangDinh, et al.
Publicado: (2018)

ThPOK Inhibits Osteoclast Formation Via NFATc1 Transcription and Function
por: Zou, Wei, et al.
Publicado: (2022)

Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation
por: Omata, Yasuhiro, et al.
Publicado: (2023)

Comparison of perioperative flurbiprofen axetil or celecoxib administration for pain management after total-knee arthroplasty: A retrospective study
por: Xiao, Xia, et al.
Publicado: (2018)

The Osteoclast in Bone Metastasis: Player and Target
por: Maurizi, Antonio, et al.
Publicado: (2018)

Serum copper levels are associated with bone mineral density and total fracture
por: Qu, Xinhua, et al.
Publicado: (2018)

Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation
por: Wu, Lili, et al.
Publicado: (2019)

Elucidation of the tumoritropic principle of hypericin
por: Van de Putte, M, et al.
Publicado: (2005)

CaSR Induces Osteoclast Differentiation and Promotes Bone Metastasis in Lung Adenocarcinoma
por: Liu, Lian, et al.
Publicado: (2020)

Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption
por: Yang, Jin-Gang, et al.
Publicado: (2023)

Zinc inhibits osteoclast differentiation by suppression of Ca(2+)-Calcineurin-NFATc1 signaling pathway
por: Park, Kwang Hwan, et al.
Publicado: (2013)

Inhibitory Effect of Purpurogallin on Osteoclast Differentiation In Vitro through the Downregulation of c-Fos and NFATc1
por: Kim, Kiryeong, et al.
Publicado: (2018)

Flavonoid Glycosides from Ulmus macrocarpa Inhibit Osteoclast Differentiation via the Downregulation of NFATc1
por: Wang, Weihong, et al.
Publicado: (2022)

Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1
por: Ibáñez, Lidia, et al.
Publicado: (2022)

The role of osteoclasts in breast cancer bone metastasis
por: Le Pape, François, et al.
Publicado: (2016)

Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway
por: Zhang, Qi, et al.
Publicado: (2022)

NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors
por: Zhong, Zeyuan, et al.
Publicado: (2023)

Hypericins as Potential Leads for New Therapeutics
por: Karioti, Anastasia, et al.
Publicado: (2010)

Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts
por: Li, Tao, et al.
Publicado: (2021)

The effect of enhanced bone marrow in conjunction with 3D-printed PLA-HA in the repair of critical-sized bone defects in a rabbit model
por: Liu, Zhiqing, et al.
Publicado: (2021)

NADPH oxidase gp91(phox) contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1
por: Kang, In Soon, et al.
Publicado: (2016)

Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1
por: Kim, Inyoung, et al.
Publicado: (2017)

Chaenomelis fructus inhibits osteoclast differentiation by suppressing NFATc1 expression and prevents ovariectomy-induced osteoporosis
por: Kim, Minsun, et al.
Publicado: (2020)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF-κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis
por: Ding, Dong, et al.
Publicado: (2022)

Knockdown of Tcirg1 inhibits large-osteoclast generation by down-regulating NFATc1 and IP3R2 expression
por: Zhang, Dongyan, et al.
Publicado: (2020)

NFATc1 self-promotes to build bone
por: Van Epps, Heather L.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_hnrripb87oiflfo1p0l78d7n90