PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high for HNSCC patients with mutations in the TP53 gene although patient...

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Detalles Bibliográficos
Autores principales: Yin, Zhi-Xian, Hang, Wei, Liu, Gang, Wang, Yi-Shu, Shen, Xiang-Feng, Sun, Qian-Hui, Li, Dong-Dong, Jian, Yong-Ping, Zhang, Yang-He, Quan, Cheng-Shi, Zeng, Qinghua, Li, Yu-Lin, Zhao, Rui-Xun, Ding, Qiang, Xu, Zhi-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788606/
https://www.ncbi.nlm.nih.gov/pubmed/29416738
http://dx.doi.org/10.18632/oncotarget.21277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788606/
https://www.ncbi.nlm.nih.gov/pubmed/29416738
http://dx.doi.org/10.18632/oncotarget.21277

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