Cargando…

microRNA-19a protects osteoblasts from dexamethasone via targeting TSC1

Activation of mTOR complex 1 (mTORC1) could protect human osteoblasts from dexamethasone. Tuberous sclerosis complex 1 (TSC1) is mTORC1 upstream inhibitory protein. We demonstrate here that microRNA-19a (“miR-19a”, -3p) targets the 3' untranslated regions of TSC1 mRNA. Expression of miR-19a dow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Gang, Chen, Feng-Li, Ji, Feng, Fei, Hao-Dong, Xie, Yue, Wang, Shou-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788617/ https://www.ncbi.nlm.nih.gov/pubmed/29416749 http://dx.doi.org/10.18632/oncotarget.23326

Ejemplares similares

MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone
por: Zhao, Sai, et al.
Publicado: (2017)

microRNA-25 targets PKCζ and protects osteoblastic cells from dexamethasone via activating AMPK signaling
por: Fan, Jian-bo, et al.
Publicado: (2016)

FGF23 protects osteoblasts from dexamethasone-induced oxidative injury
por: Ji, Feng, et al.
Publicado: (2020)

MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells
por: Li, Peng, et al.
Publicado: (2021)

Icariside II activates EGFR-Akt-Nrf2 signaling and protects osteoblasts from dexamethasone
por: Liu, Weidong, et al.
Publicado: (2016)

Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade
por: Liang, Jin-qian, et al.
Publicado: (2021)

Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress
por: Guo, Shiguang, et al.
Publicado: (2017)

MicroRNA-21 facilitates osteoblast activity
por: Oka, Shunichi, et al.
Publicado: (2020)

MicroRNA Expression Profile in TSC Cell Lines and the Impact of mTOR Inhibitor
por: Pawlik, Bartłomiej, et al.
Publicado: (2022)

DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts
por: Chen, Jing, et al.
Publicado: (2021)

MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM)
por: Trindade, Anil J., et al.
Publicado: (2013)

MicroRNA‐142 regulates osteoblast differentiation and apoptosis of mouse pre‐osteoblast cells by targeting bone morphogenetic protein 2
por: Luo, Bing, et al.
Publicado: (2020)

microRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide
por: Xu, Dawei, et al.
Publicado: (2017)

MicroRNA-671-3p promotes proliferation and migration of glioma cells via targeting CKAP4
por: Lu, Gui-Feng, et al.
Publicado: (2018)

MicroRNA-409-3p promotes osteoblastic differentiation via activation of Wnt/β-catenin signaling pathway by targeting SCAI
por: Chen, Nan, et al.
Publicado: (2021)

Dexamethasone Down-Regulates the Expression of microRNA-155 in the Livers of Septic Mice
por: Wang, Zhong-hua, et al.
Publicado: (2013)

miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity
por: Zhuang, Yu, et al.
Publicado: (2020)

Improving performance of mammalian microRNA target prediction
por: Liu, Hui, et al.
Publicado: (2010)

MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR
por: Geng, Hongwei, et al.
Publicado: (2020)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Understanding cooperativity of microRNAs via microRNA association networks
por: Na, Young-Ji, et al.
Publicado: (2013)

MicroRNA-1270 Inhibits Cell Proliferation, Migration, and Invasion via Targeting IRF8 in Osteoblast-like Cell Lines
por: Ramírez-Salazar, Eric Gustavo, et al.
Publicado: (2022)

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity
por: Sun, Weijia, et al.
Publicado: (2016)

MicroRNA-186-5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non-traumatic osteonecrosis
por: Xu, Weihua, et al.
Publicado: (2019)

MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma
por: Wang, Cong, et al.
Publicado: (2020)

MicroRNA-532-5p is implicated in the regulation of osteoporosis by forkhead box O1 and osteoblast differentiation
por: Guo, Xinyu, et al.
Publicado: (2020)

Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Autophagy and Mitophagy Thereby Restoring Osteoblast Function In Vitro and In Vivo
por: Chen, Liang, et al.
Publicado: (2020)

Icariin ameliorates dexamethasone-induced bone deterioration in an experimental mouse model via activation of microRNA-186 inhibition of cathepsin K
por: Ma, Yongsheng, et al.
Publicado: (2018)

MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin
por: Lian, Wei-Shiung, et al.
Publicado: (2021)

MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM
por: Wang, Yixuan, et al.
Publicado: (2018)

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients
por: Jiangyi, Wang, et al.
Publicado: (2020)

MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression
por: Tang, Xiaolin, et al.
Publicado: (2017)

MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathway
por: Zhao, Huiqing, et al.
Publicado: (2020)

Hyperoside protects cardiomyocytes against hypoxia-induced injury via upregulation of microRNA-138
por: He, Siyi, et al.
Publicado: (2021)

Export of microRNAs and microRNA-protective protein by mammalian cells
por: Wang, Kai, et al.
Publicado: (2010)

MicroRNA Let-7d-3p Contributes to Cardiac Protection via Targeting HMGA2
por: Wong, Lee Lee, et al.
Publicado: (2019)

Crocin protects against dexamethasone-induced osteoblast apoptosis by inhibiting the ROS/Ca(2+)-mediated mitochondrial pathway
por: Nie, Zhigang, et al.
Publicado: (2019)

Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells
por: Li, ChunYu, et al.
Publicado: (2017)

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
por: Rosengren, Thomas, et al.
Publicado: (2018)

MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1
por: Dai, Feng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6e73jp9h4g2vn4ulgfjer3maq8