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SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer

ncRNAs are important regulatory molecules and involve in many physiological cellular processes. Small nucleolar RNA host gene 1 (SNHG1) is a host to 8 snoRNAs and is located in 11q12.3 region of the chromosome. It has been reported to be involved in several cancers. However, the role of SNHG1 in the...

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Autores principales: Tian, Tian, Qiu, Ran, Qiu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788627/
https://www.ncbi.nlm.nih.gov/pubmed/29416759
http://dx.doi.org/10.18632/oncotarget.23255
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author Tian, Tian
Qiu, Ran
Qiu, Xia
author_facet Tian, Tian
Qiu, Ran
Qiu, Xia
author_sort Tian, Tian
collection PubMed
description ncRNAs are important regulatory molecules and involve in many physiological cellular processes. Small nucleolar RNA host gene 1 (SNHG1) is a host to 8 snoRNAs and is located in 11q12.3 region of the chromosome. It has been reported to be involved in several cancers. However, the role of SNHG1 in the tumorigenesis of colorectal cancer is still unknown. In this study, SNHG1 was upregulated in colorectal cancers, and SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence. We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer. Furthermore, the survival analysis indicated that colorectal cancer patients with higher expression of SNHG1 had a worse prognosis. These findings suggested that SNHG1 may act as a potential therapeutic target for the treatment of colorectal cancer.
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spelling pubmed-57886272018-02-07 SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer Tian, Tian Qiu, Ran Qiu, Xia Oncotarget Research Paper ncRNAs are important regulatory molecules and involve in many physiological cellular processes. Small nucleolar RNA host gene 1 (SNHG1) is a host to 8 snoRNAs and is located in 11q12.3 region of the chromosome. It has been reported to be involved in several cancers. However, the role of SNHG1 in the tumorigenesis of colorectal cancer is still unknown. In this study, SNHG1 was upregulated in colorectal cancers, and SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence. We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer. Furthermore, the survival analysis indicated that colorectal cancer patients with higher expression of SNHG1 had a worse prognosis. These findings suggested that SNHG1 may act as a potential therapeutic target for the treatment of colorectal cancer. Impact Journals LLC 2017-12-14 /pmc/articles/PMC5788627/ /pubmed/29416759 http://dx.doi.org/10.18632/oncotarget.23255 Text en Copyright: © 2018 Tian et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Tian, Tian
Qiu, Ran
Qiu, Xia
SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title_full SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title_fullStr SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title_full_unstemmed SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title_short SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer
title_sort snhg1 promotes cell proliferation by acting as a sponge of mir-145 in colorectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788627/
https://www.ncbi.nlm.nih.gov/pubmed/29416759
http://dx.doi.org/10.18632/oncotarget.23255
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