Cargando…

Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models

Acquired resistance to chemo-drugs remains a major obstacle to successful cancer therapy. Metformin, a well-documented drug for treating type II diabetes, was recently proposed as a novel agent for tumor treatment. In this study, we found that metformin suppressed MCF7/ADR, a doxorubicin-resistant b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ying, Wang, Meng, Zhi, Pei, You, Jian, Gao, Jian-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788630/ https://www.ncbi.nlm.nih.gov/pubmed/29416762 http://dx.doi.org/10.18632/oncotarget.23187

Ejemplares similares

Knockdown of SALL4 inhibits the proliferation and reverses the resistance of MCF-7/ADR cells to doxorubicin hydrochloride
por: Chen, Yuan-Yuan, et al.
Publicado: (2016)

Synergistic effects of A-B-C-type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma
por: Zhang, Lu, et al.
Publicado: (2016)

Identification of co-regulated genes associated with doxorubicin resistance in the MCF-7/ADR cancer cell line
por: Miri, Ali, et al.
Publicado: (2023)

Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells
por: Jeon, Yong-Joon, et al.
Publicado: (2016)

Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase
por: Yang, Ronghui, et al.
Publicado: (2021)

A Novel Submicron Emulsion System Loaded with Doxorubicin Overcome Multi-Drug Resistance in MCF-7/ADR Cells
por: Zhou, W. P., et al.
Publicado: (2015)

The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivo
por: Wang, Chao, et al.
Publicado: (2015)

Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells
por: Liu, Ming, et al.
Publicado: (2016)

Prenylflavonoid Isoxanthohumol Sensitizes MCF-7/ADR Cells to Doxorubicin Cytotoxicity via Acting as a Substrate of ABCB1
por: Liu, Ming, et al.
Publicado: (2017)

Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7(ADR) breast cancer cells
por: Abdel-Sattar, Ola E., et al.
Publicado: (2023)

Preparation of psoralen polymer–lipid hybrid nanoparticles and their reversal of multidrug resistance in MCF-7/ADR cells
por: Huang, Qingqing, et al.
Publicado: (2018)

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin
por: Xue, Chaojun, et al.
Publicado: (2016)

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1
por: Wei, Jinrong, et al.
Publicado: (2014)

CIP2A silencing alleviates doxorubicin resistance in MCF7/ADR cells through activating PP2A and autophagy
por: Zhu, Z., et al.
Publicado: (2021)

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway
por: Yang, Lin, et al.
Publicado: (2020)

Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells
por: Tun, Jortan O., et al.
Publicado: (2019)

A Novel Electrochemical Differentiation between Exosomal-RNA of Breast Cancer MCF7 and MCF7/ADR-Resistant Cells
por: Abdelaziz, Mohammed H., et al.
Publicado: (2023)

Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
por: Wang, Xu, et al.
Publicado: (2019)

PA‐MSHA inhibits the growth of doxorubicin‐resistant MCF‐7/ADR human breast cancer cells by downregulating Nrf2/p62
por: Wei, Yingze, et al.
Publicado: (2016)

Preparation and evaluation of poly(l-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells
por: Jia, Nan, et al.
Publicado: (2017)

Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin
por: Abdalla, Ashraf N., et al.
Publicado: (2021)

Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier
por: Li, Jin-Ming, et al.
Publicado: (2015)

Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
por: Budworth, J., et al.
Publicado: (1996)

The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells
por: Wu, Long, et al.
Publicado: (2014)

Corrigendum: Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
por: Wang, Xu, et al.
Publicado: (2020)

A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression
por: Wang, Ting, et al.
Publicado: (2021)

Cyperotundone combined with adriamycin induces apoptosis in MCF-7 and MCF-7/ADR cancer cells by ROS generation and NRF2/ARE signaling pathway
por: Shao, Wenna, et al.
Publicado: (2023)

Effect of CIK on multidrug-resistance reversal and increasing the sensitivity of ADR in K562/ADR cells
por: WANG, LEI, et al.
Publicado: (2014)

Synergistic combination of doxorubicin with hydralazine, and disulfiram against MCF-7 breast cancer cell line
por: Lafi, Zainab, et al.
Publicado: (2023)

Enhanced delivery of PEAL nanoparticles with ultrasound targeted microbubble destruction mediated siRNA transfection in human MCF-7/S and MCF-7/ADR cells in vitro
por: Teng, Yanwei, et al.
Publicado: (2015)

Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1
por: Wang, Changyuan, et al.
Publicado: (2016)

Synergistic cytotoxic effects of an extremely low-frequency electromagnetic field with doxorubicin on MCF-7 cell line
por: Ramazi, Shahin, et al.
Publicado: (2023)

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels
por: Al‑Harbi, Lali M., et al.
Publicado: (2023)

Proteins from Lignosus tigris with selective apoptotic cytotoxicity towards MCF7 cell line and suppresses MCF7-xenograft tumor growth
por: Kong, Boon Hong, et al.
Publicado: (2020)

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells
por: Sun, Wenxia, et al.
Publicado: (2013)

In Vitro Cytotoxic Study of Euphorbia grantii Oliv. Aerial Parts against MCF-7 and MCF-7(ADR) Breast Cancer Cell Lines: A Bioactivity-Guided Isolation
por: Radi, Mai Hussin, et al.
Publicado: (2023)

Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells
por: Ku, Jin Mo, et al.
Publicado: (2015)

Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects
por: Albalawi, Fawzia F., et al.
Publicado: (2022)

Downregulation of eIF4G by microRNA-503 enhances drug sensitivity of MCF-7/ADR cells through suppressing the expression of ABC transport proteins
por: Pan, Xia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_u51bmhs3mkv2sv169c92jo3jug