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Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer
Colorectal cancer is very common worldwide and advanced colorectal cancer exhibited very poor clinical outcome. Oxaliplatin (OXP) is one of the principal chemotherapeutic agents in colorectal cancer treatment presenting impressive anti-tumor ability, limited by adverse effect in clinical practice. F...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788656/ https://www.ncbi.nlm.nih.gov/pubmed/29416788 http://dx.doi.org/10.18632/oncotarget.23507 |
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author | Hu, Yuzhu Yu, Ting Liu, Xiaoxiao He, Yihong Deng, Lihong Guo, Jiajuan Hua, Yuanqi Luo, Ting Gao, Xiang |
author_facet | Hu, Yuzhu Yu, Ting Liu, Xiaoxiao He, Yihong Deng, Lihong Guo, Jiajuan Hua, Yuanqi Luo, Ting Gao, Xiang |
author_sort | Hu, Yuzhu |
collection | PubMed |
description | Colorectal cancer is very common worldwide and advanced colorectal cancer exhibited very poor clinical outcome. Oxaliplatin (OXP) is one of the principal chemotherapeutic agents in colorectal cancer treatment presenting impressive anti-tumor ability, limited by adverse effect in clinical practice. Fibrin glue (FG) is a biocompatible formulation made of fibrinogen and thrombin, extensively used in surgery for hemostasis, tissue adhesion and sealing. In this study, FG was innovatively applied as OXP delivery system and results showed enhanced anti-tumor performance in subcutaneous model and abdominal metastasis model of murine colorectal cancer compared with that of OXP used alone. It is revealed that combination of OXP and FG could increase activated CD8(+) T cells, reduce regulatory T (Treg) cells and increase interferon-γ (IFN-γ). Furthermore, results showed promoted tumor apoptosis, decreased proliferation and inhibited tumor angiogenesis by OXP and FG combination. No obvious systemic toxicity was observed in this study. Finally, our findings provided basis for promising application of OXP and FG combination in colorectal cancer treatment. |
format | Online Article Text |
id | pubmed-5788656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57886562018-02-07 Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer Hu, Yuzhu Yu, Ting Liu, Xiaoxiao He, Yihong Deng, Lihong Guo, Jiajuan Hua, Yuanqi Luo, Ting Gao, Xiang Oncotarget Research Paper Colorectal cancer is very common worldwide and advanced colorectal cancer exhibited very poor clinical outcome. Oxaliplatin (OXP) is one of the principal chemotherapeutic agents in colorectal cancer treatment presenting impressive anti-tumor ability, limited by adverse effect in clinical practice. Fibrin glue (FG) is a biocompatible formulation made of fibrinogen and thrombin, extensively used in surgery for hemostasis, tissue adhesion and sealing. In this study, FG was innovatively applied as OXP delivery system and results showed enhanced anti-tumor performance in subcutaneous model and abdominal metastasis model of murine colorectal cancer compared with that of OXP used alone. It is revealed that combination of OXP and FG could increase activated CD8(+) T cells, reduce regulatory T (Treg) cells and increase interferon-γ (IFN-γ). Furthermore, results showed promoted tumor apoptosis, decreased proliferation and inhibited tumor angiogenesis by OXP and FG combination. No obvious systemic toxicity was observed in this study. Finally, our findings provided basis for promising application of OXP and FG combination in colorectal cancer treatment. Impact Journals LLC 2017-12-20 /pmc/articles/PMC5788656/ /pubmed/29416788 http://dx.doi.org/10.18632/oncotarget.23507 Text en Copyright: © 2018 Hu et al. https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hu, Yuzhu Yu, Ting Liu, Xiaoxiao He, Yihong Deng, Lihong Guo, Jiajuan Hua, Yuanqi Luo, Ting Gao, Xiang Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title | Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title_full | Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title_fullStr | Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title_full_unstemmed | Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title_short | Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
title_sort | improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788656/ https://www.ncbi.nlm.nih.gov/pubmed/29416788 http://dx.doi.org/10.18632/oncotarget.23507 |
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