IL-36 cytokines in autoimmunity and inflammatory disease

The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogen...

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Detalles Bibliográficos
Autores principales: Ding, Liping, Wang, Xiaohui, Hong, Xiaoping, Lu, Liwei, Liu, Dongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788690/
https://www.ncbi.nlm.nih.gov/pubmed/29416822
http://dx.doi.org/10.18632/oncotarget.22814
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author Ding, Liping
Wang, Xiaohui
Hong, Xiaoping
Lu, Liwei
Liu, Dongzhou
author_facet Ding, Liping
Wang, Xiaohui
Hong, Xiaoping
Lu, Liwei
Liu, Dongzhou
author_sort Ding, Liping
collection PubMed
description The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a brief review on the activation of IL-36 family cytokines and their involvement in autoimmunity and inflammatory diseases, which will provide further insights in understanding the functions of IL-36 family cytokines in the pathophysiology of autoimmunity and inflammatory diseases.
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spelling pubmed-57886902018-02-07 IL-36 cytokines in autoimmunity and inflammatory disease Ding, Liping Wang, Xiaohui Hong, Xiaoping Lu, Liwei Liu, Dongzhou Oncotarget Review The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a brief review on the activation of IL-36 family cytokines and their involvement in autoimmunity and inflammatory diseases, which will provide further insights in understanding the functions of IL-36 family cytokines in the pathophysiology of autoimmunity and inflammatory diseases. Impact Journals LLC 2017-12-01 /pmc/articles/PMC5788690/ /pubmed/29416822 http://dx.doi.org/10.18632/oncotarget.22814 Text en Copyright: © 2018 Ding et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Ding, Liping
Wang, Xiaohui
Hong, Xiaoping
Lu, Liwei
Liu, Dongzhou
IL-36 cytokines in autoimmunity and inflammatory disease
title IL-36 cytokines in autoimmunity and inflammatory disease
title_full IL-36 cytokines in autoimmunity and inflammatory disease
title_fullStr IL-36 cytokines in autoimmunity and inflammatory disease
title_full_unstemmed IL-36 cytokines in autoimmunity and inflammatory disease
title_short IL-36 cytokines in autoimmunity and inflammatory disease
title_sort il-36 cytokines in autoimmunity and inflammatory disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788690/
https://www.ncbi.nlm.nih.gov/pubmed/29416822
http://dx.doi.org/10.18632/oncotarget.22814
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AT luliwei il36cytokinesinautoimmunityandinflammatorydisease
AT liudongzhou il36cytokinesinautoimmunityandinflammatorydisease

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