Cargando…
Prognosis of men with penile metastasis and malignant priapism: a systematic review
Introduction: Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease. We reviewed the literature relating to all case reports,...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788693/ https://www.ncbi.nlm.nih.gov/pubmed/29416825 http://dx.doi.org/10.18632/oncotarget.23366 |
_version_ | 1783296126133207040 |
---|---|
author | Cocci, Andrea Hakenberg, Oliver W. Cai, Tommaso Nesi, Gabriella Livi, Lorenzo Detti, Beatrice Minervini, Andrea Morelli, Girolamo Carini, Marco Serni, Sergio Gacci, Mauro |
author_facet | Cocci, Andrea Hakenberg, Oliver W. Cai, Tommaso Nesi, Gabriella Livi, Lorenzo Detti, Beatrice Minervini, Andrea Morelli, Girolamo Carini, Marco Serni, Sergio Gacci, Mauro |
author_sort | Cocci, Andrea |
collection | PubMed |
description | Introduction: Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease. We reviewed the literature relating to all case reports, series and reviews about penile metastasis, from 2003 to 2013, through a Medline search. We identified 63 articles and 69 patients. Metastases were located on the root (38.8%), the shaft (38.8%) or the glans (22.2%) of the penis. The diagnosis of penile metastasis was made after the primary cancer had been diagnosed. The most common presentation was a single small penile nodule. Ten patients reported priapism. The median survival time after diagnosis of penile metastasis was 10 months (range 6-18 months). A Kaplan-Meier analysis has shown that the patients presenting with priapism and those with metastases from non-urologic tumors have a significantly worse prognosis (age adjusted Log Rank: p=0.037 for priapism vs. no priapism and p=0.045 for urologic vs. non urologic). There are prognostic differences based on the presentation of penile metastases. Survival is substantial and treatment should therefore take into account symptoms improvement and quality of life. |
format | Online Article Text |
id | pubmed-5788693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57886932018-02-07 Prognosis of men with penile metastasis and malignant priapism: a systematic review Cocci, Andrea Hakenberg, Oliver W. Cai, Tommaso Nesi, Gabriella Livi, Lorenzo Detti, Beatrice Minervini, Andrea Morelli, Girolamo Carini, Marco Serni, Sergio Gacci, Mauro Oncotarget Review Introduction: Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease. We reviewed the literature relating to all case reports, series and reviews about penile metastasis, from 2003 to 2013, through a Medline search. We identified 63 articles and 69 patients. Metastases were located on the root (38.8%), the shaft (38.8%) or the glans (22.2%) of the penis. The diagnosis of penile metastasis was made after the primary cancer had been diagnosed. The most common presentation was a single small penile nodule. Ten patients reported priapism. The median survival time after diagnosis of penile metastasis was 10 months (range 6-18 months). A Kaplan-Meier analysis has shown that the patients presenting with priapism and those with metastases from non-urologic tumors have a significantly worse prognosis (age adjusted Log Rank: p=0.037 for priapism vs. no priapism and p=0.045 for urologic vs. non urologic). There are prognostic differences based on the presentation of penile metastases. Survival is substantial and treatment should therefore take into account symptoms improvement and quality of life. Impact Journals LLC 2017-12-18 /pmc/articles/PMC5788693/ /pubmed/29416825 http://dx.doi.org/10.18632/oncotarget.23366 Text en Copyright: © 2018 Cocci et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Cocci, Andrea Hakenberg, Oliver W. Cai, Tommaso Nesi, Gabriella Livi, Lorenzo Detti, Beatrice Minervini, Andrea Morelli, Girolamo Carini, Marco Serni, Sergio Gacci, Mauro Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title | Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title_full | Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title_fullStr | Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title_full_unstemmed | Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title_short | Prognosis of men with penile metastasis and malignant priapism: a systematic review |
title_sort | prognosis of men with penile metastasis and malignant priapism: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788693/ https://www.ncbi.nlm.nih.gov/pubmed/29416825 http://dx.doi.org/10.18632/oncotarget.23366 |
work_keys_str_mv | AT cocciandrea prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT hakenbergoliverw prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT caitommaso prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT nesigabriella prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT livilorenzo prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT dettibeatrice prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT minerviniandrea prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT morelligirolamo prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT carinimarco prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT sernisergio prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview AT gaccimauro prognosisofmenwithpenilemetastasisandmalignantpriapismasystematicreview |