An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction....

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Hongjie, Luo, Huanle, Shan, Chao, Muruato, Antonio E., Nunes, Bruno T. D., Medeiros, Daniele B. A., Zou, Jing, Xie, Xuping, Giraldo, Maria Isabel, Vasconcelos, Pedro F. C., Weaver, Scott C., Wang, Tian, Rajsbaum, Ricardo, Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788864/
https://www.ncbi.nlm.nih.gov/pubmed/29379028
http://dx.doi.org/10.1038/s41467-017-02816-2

Ejemplares similares

Ejemplares similares