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A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion
Plants pre-infected with a mild variant of a virus frequently become protected against more severe variants of the same virus through the cross protection phenomenon first discovered in 1929. Despite its widespread use in managing important plant virus diseases, the mechanism of cross protection rem...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788904/ https://www.ncbi.nlm.nih.gov/pubmed/29422912 http://dx.doi.org/10.3389/fpls.2018.00040 |
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author | Zhang, Xiao-Feng Zhang, Shaoyan Guo, Qin Sun, Rong Wei, Taiyun Qu, Feng |
author_facet | Zhang, Xiao-Feng Zhang, Shaoyan Guo, Qin Sun, Rong Wei, Taiyun Qu, Feng |
author_sort | Zhang, Xiao-Feng |
collection | PubMed |
description | Plants pre-infected with a mild variant of a virus frequently become protected against more severe variants of the same virus through the cross protection phenomenon first discovered in 1929. Despite its widespread use in managing important plant virus diseases, the mechanism of cross protection remains poorly understood. Recent investigations in our labs, by analyzing the whole-plant dynamics of a turnip crinkle virus (TCV) population, coupled with cell biological interrogation of individual TCV variants, revealed possible novel mechanisms for cross protection and the closely related process of superinfection exclusion (SIE). Our new mechanistic model postulates that, for RNA viruses like TCV, SIE manifests a viral function that denies progeny viruses the chance of re-replicating their genomes in the cells of their “parents,” and it collaterally targets highly homologous superinfecting viruses that are indistinguishable from progeny viruses. We further propose that SIE may be evolutionarily selected to maintain an optimal error frequency in progeny genomes. Although primarily based on observations made with TCV, this new model could be broadly applicable to other viruses as it provides a molecular basis for maintaining virus genome fidelity in the face of the error-prone nature of virus replication process. |
format | Online Article Text |
id | pubmed-5788904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57889042018-02-08 A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion Zhang, Xiao-Feng Zhang, Shaoyan Guo, Qin Sun, Rong Wei, Taiyun Qu, Feng Front Plant Sci Plant Science Plants pre-infected with a mild variant of a virus frequently become protected against more severe variants of the same virus through the cross protection phenomenon first discovered in 1929. Despite its widespread use in managing important plant virus diseases, the mechanism of cross protection remains poorly understood. Recent investigations in our labs, by analyzing the whole-plant dynamics of a turnip crinkle virus (TCV) population, coupled with cell biological interrogation of individual TCV variants, revealed possible novel mechanisms for cross protection and the closely related process of superinfection exclusion (SIE). Our new mechanistic model postulates that, for RNA viruses like TCV, SIE manifests a viral function that denies progeny viruses the chance of re-replicating their genomes in the cells of their “parents,” and it collaterally targets highly homologous superinfecting viruses that are indistinguishable from progeny viruses. We further propose that SIE may be evolutionarily selected to maintain an optimal error frequency in progeny genomes. Although primarily based on observations made with TCV, this new model could be broadly applicable to other viruses as it provides a molecular basis for maintaining virus genome fidelity in the face of the error-prone nature of virus replication process. Frontiers Media S.A. 2018-01-25 /pmc/articles/PMC5788904/ /pubmed/29422912 http://dx.doi.org/10.3389/fpls.2018.00040 Text en Copyright © 2018 Zhang, Zhang, Guo, Sun, Wei and Qu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Zhang, Xiao-Feng Zhang, Shaoyan Guo, Qin Sun, Rong Wei, Taiyun Qu, Feng A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title_full | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title_fullStr | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title_full_unstemmed | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title_short | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion |
title_sort | new mechanistic model for viral cross protection and superinfection exclusion |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788904/ https://www.ncbi.nlm.nih.gov/pubmed/29422912 http://dx.doi.org/10.3389/fpls.2018.00040 |
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