Firewalls Prevent Systemic Dissemination of Vectors Derived from Human Adenovirus Type 5 and Suppress Production of Transgene-Encoded Antigen in a Murine Model of Oral Vaccination

To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastri...

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Detalles Bibliográficos
Autores principales: Revaud, Julien, Unterfinger, Yves, Rol, Nicolas, Suleman, Muhammad, Shaw, Julia, Galea, Sandra, Gavard, Françoise, Lacour, Sandrine A., Coulpier, Muriel, Versillé, Nicolas, Havenga, Menzo, Klonjkowski, Bernard, Zanella, Gina, Biacchesi, Stéphane, Cordonnier, Nathalie, Corthésy, Blaise, Ben Arous, Juliette, Richardson, Jennifer P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788964/
https://www.ncbi.nlm.nih.gov/pubmed/29423380
http://dx.doi.org/10.3389/fcimb.2018.00006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788964/
https://www.ncbi.nlm.nih.gov/pubmed/29423380
http://dx.doi.org/10.3389/fcimb.2018.00006

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