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Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAG(n51trunc) Model of Huntington Disease

The transgenic rat model of Huntington disease expressing a fragment of mutant HTT (tgHD rat) has been thoroughly characterized and reproduces hallmark symptoms of human adult-onset HD. Pursuing the optimization of this model for evaluation of translational therapeutic approaches, the F344 inbred ra...

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Detalles Bibliográficos
Autores principales:	Plank, Anne-Christine, Canneva, Fabio, Raber, Kerstin A., Urbach, Yvonne K., Dobner, Julia, Puchades, Maja, Bjaalie, Jan G., Gillmann, Clarissa, Bäuerle, Tobias, Riess, Olaf, Nguyen, Hoa H. P., von Hörsten, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788972/ https://www.ncbi.nlm.nih.gov/pubmed/29422836 http://dx.doi.org/10.3389/fnins.2018.00011

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