A novel mouse model carrying a human cytoplasmic dynein mutation shows motor behavior deficits consistent with Charcot-Marie-Tooth type 2O disease

Charcot-Marie-Tooth disease (CMT) is a peripheral neuromuscular disorder in which axonal degeneration causes progressive loss of motor and sensory nerve function. The loss of motor nerve function leads to distal muscle weakness and atrophy, resulting in gait problems and difficulties with walking, r...

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Detalles Bibliográficos
Autores principales: Sabblah, Thywill T., Nandini, Swaran, Ledray, Aaron P., Pasos, Julio, Calderon, Jami L. Conley, Love, Rachal, King, Linda E., King, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789002/
https://www.ncbi.nlm.nih.gov/pubmed/29379136
http://dx.doi.org/10.1038/s41598-018-20081-1

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