Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase

An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands with potential therapeutic value. Here, we report the discovery and characterization of an all...

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Detalles Bibliográficos
Autores principales: Tyukhtenko, Sergiy, Rajarshi, Girija, Karageorgos, Ioannis, Zvonok, Nikolai, Gallagher, Elyssia S., Huang, Hongwei, Vemuri, Kiran, Hudgens, Jeffrey W., Ma, Xiaoyu, Nasr, Mahmoud L., Pavlopoulos, Spiro, Makriyannis, Alexandros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789057/
https://www.ncbi.nlm.nih.gov/pubmed/29379013
http://dx.doi.org/10.1038/s41598-017-19135-7

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