Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to ac...

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Autores principales: Muthusamy, Nagendran, Brumm, Andrew, Zhang, Xuying, Carmichael, S. Thomas, Ghashghaei, H. Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789075/
https://www.ncbi.nlm.nih.gov/pubmed/29379049
http://dx.doi.org/10.1038/s41598-018-19913-x
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author Muthusamy, Nagendran
Brumm, Andrew
Zhang, Xuying
Carmichael, S. Thomas
Ghashghaei, H. Troy
author_facet Muthusamy, Nagendran
Brumm, Andrew
Zhang, Xuying
Carmichael, S. Thomas
Ghashghaei, H. Troy
author_sort Muthusamy, Nagendran
collection PubMed
description The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
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spelling pubmed-57890752018-02-08 Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain Muthusamy, Nagendran Brumm, Andrew Zhang, Xuying Carmichael, S. Thomas Ghashghaei, H. Troy Sci Rep Article The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated. Nature Publishing Group UK 2018-01-29 /pmc/articles/PMC5789075/ /pubmed/29379049 http://dx.doi.org/10.1038/s41598-018-19913-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Muthusamy, Nagendran
Brumm, Andrew
Zhang, Xuying
Carmichael, S. Thomas
Ghashghaei, H. Troy
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title_full Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title_fullStr Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title_full_unstemmed Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title_short Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
title_sort foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789075/
https://www.ncbi.nlm.nih.gov/pubmed/29379049
http://dx.doi.org/10.1038/s41598-018-19913-x
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