Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo

We generated induced pluripotent stem cells (iPSCs) from patient fibroblasts to yield cell lines containing varying degrees of heteroplasmy for a m.13514 A > G mtDNA point mutation (2 lines) and for a ~6 kb single, large scale mtDNA deletion (3 lines). Long term culture of the iPSCs containing a ...

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Detalles Bibliográficos
Autores principales: Russell, Oliver M., Fruh, Isabelle, Rai, Pavandeep K., Marcellin, David, Doll, Thierry, Reeve, Amy, Germain, Mitchel, Bastien, Julie, Rygiel, Karolina A., Cerino, Raffaele, Sailer, Andreas W., Lako, Majlinda, Taylor, Robert W., Mueller, Matthias, Lightowlers, Robert N., Turnbull, Doug M., Helliwell, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789095/
https://www.ncbi.nlm.nih.gov/pubmed/29379065
http://dx.doi.org/10.1038/s41598-018-20064-2

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