Intra- and Intercellular Quality Control Mechanisms of Mitochondria

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellula...

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Detalles Bibliográficos
Autores principales: Kiriyama, Yoshimitsu, Nochi, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789274/
https://www.ncbi.nlm.nih.gov/pubmed/29278362
http://dx.doi.org/10.3390/cells7010001
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author Kiriyama, Yoshimitsu
Nochi, Hiromi
author_facet Kiriyama, Yoshimitsu
Nochi, Hiromi
author_sort Kiriyama, Yoshimitsu
collection PubMed
description Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.
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spelling pubmed-57892742018-02-02 Intra- and Intercellular Quality Control Mechanisms of Mitochondria Kiriyama, Yoshimitsu Nochi, Hiromi Cells Review Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria. MDPI 2017-12-26 /pmc/articles/PMC5789274/ /pubmed/29278362 http://dx.doi.org/10.3390/cells7010001 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kiriyama, Yoshimitsu
Nochi, Hiromi
Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title_full Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title_fullStr Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title_full_unstemmed Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title_short Intra- and Intercellular Quality Control Mechanisms of Mitochondria
title_sort intra- and intercellular quality control mechanisms of mitochondria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789274/
https://www.ncbi.nlm.nih.gov/pubmed/29278362
http://dx.doi.org/10.3390/cells7010001
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