Targeting FLT3 Mutations in Acute Myeloid Leukemia

The FMS-like tyrosine kinase 3 (FLT3) pathway has an important role in cellular proliferation, survival, and differentiation. Acute myeloid leukemia (AML) patients with mutated FLT3 have a large disease burden at presentation and a dismal prognosis. A number of FLT3 inhibitors have been developed ov...

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Detalles Bibliográficos
Autores principales: El Fakih, Riad, Rasheed, Walid, Hawsawi, Yousef, Alsermani, Maamoun, Hassanein, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789277/
https://www.ncbi.nlm.nih.gov/pubmed/29316714
http://dx.doi.org/10.3390/cells7010004

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