Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H(2)O(2)-Dependent Manner

Lung cancer, together with head and neck cancer, accounts for more than one-fourth of cancer deaths worldwide. New, non-toxic therapeutic approaches are needed. High-dose IV vitamin C (aka, pharmacological ascorbate; P-AscH(−)) represents a promising adjuvant to radiochemotherapy that exerts its ant...

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Autores principales: Heer, Collin D., Davis, Andrew B., Riffe, David B., Wagner, Brett A., Falls, Kelly C., Allen, Bryan G., Buettner, Garry R., Beardsley, Robert A., Riley, Dennis P., Spitz, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789328/
https://www.ncbi.nlm.nih.gov/pubmed/29351198
http://dx.doi.org/10.3390/antiox7010018

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