Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via nucleophilic addition and subsequent intramole...

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Detalles Bibliográficos
Autores principales: Inaba, Masanori, Sakai, Tatsuya, Shinada, Shun, Sugiishi, Tsuyuka, Nishina, Yuta, Shibata, Norio, Amii, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789380/
https://www.ncbi.nlm.nih.gov/pubmed/29441140
http://dx.doi.org/10.3762/bjoc.14.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789380/
https://www.ncbi.nlm.nih.gov/pubmed/29441140
http://dx.doi.org/10.3762/bjoc.14.12

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