Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion

Respiratory syncytial virus–bronchiolitis is a major independent risk factor for subsequent asthma, but the causal mechanisms remain obscure. We identified that transient plasmacytoid dendritic cell (pDC) depletion during primary Pneumovirus infection alone predisposed to severe bronchiolitis in ear...

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Detalles Bibliográficos
Autores principales: Lynch, Jason P., Werder, Rhiannon B., Loh, Zhixuan, Sikder, Md. Al Amin, Curren, Bodie, Zhang, Vivian, Rogers, Matthew J., Lane, Katie, Simpson, Jennifer, Mazzone, Stuart B., Spann, Kirsten, Hayball, John, Diener, Kerrilyn, Everard, Mark L., Blyth, Christopher C., Forstner, Christian, Dennis, Paul G., Murtaza, Nida, Morrison, Mark, Ó Cuív, Páraic, Zhang, Ping, Haque, Ashraful, Hill, Geoffrey R., Sly, Peter D., Upham, John W., Phipps, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789405/
https://www.ncbi.nlm.nih.gov/pubmed/29273643
http://dx.doi.org/10.1084/jem.20170298

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