Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation

Mucosal Langerhans cells (LCs) originate from pre–dendritic cells and monocytes. However, the mechanisms involved in their in situ development remain unclear. Here, we demonstrate that the differentiation of murine mucosal LCs is a two-step process. In the lamina propria, signaling via BMP7-ALK3 pro...

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Detalles Bibliográficos
Autores principales: Capucha, Tal, Koren, Noam, Nassar, Maria, Heyman, Oded, Nir, Tsipora, Levy, Maayan, Zilberman-Schapira, Gili, Zelentova, Katya, Eli-Berchoer, Luba, Zenke, Martin, Hieronymus, Thomas, Wilensky, Asaf, Bercovier, Herve, Elinav, Eran, Clausen, Björn E., Hovav, Avi-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789418/
https://www.ncbi.nlm.nih.gov/pubmed/29343501
http://dx.doi.org/10.1084/jem.20171508

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