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Alzheimer’s disease hypothesis and related therapies
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, ch...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789526/ https://www.ncbi.nlm.nih.gov/pubmed/29423193 http://dx.doi.org/10.1186/s40035-018-0107-y |
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author | Du, Xiaoguang Wang, Xinyi Geng, Meiyu |
author_facet | Du, Xiaoguang Wang, Xinyi Geng, Meiyu |
author_sort | Du, Xiaoguang |
collection | PubMed |
description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies. |
format | Online Article Text |
id | pubmed-5789526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57895262018-02-08 Alzheimer’s disease hypothesis and related therapies Du, Xiaoguang Wang, Xinyi Geng, Meiyu Transl Neurodegener Review Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies. BioMed Central 2018-01-30 /pmc/articles/PMC5789526/ /pubmed/29423193 http://dx.doi.org/10.1186/s40035-018-0107-y Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Du, Xiaoguang Wang, Xinyi Geng, Meiyu Alzheimer’s disease hypothesis and related therapies |
title | Alzheimer’s disease hypothesis and related therapies |
title_full | Alzheimer’s disease hypothesis and related therapies |
title_fullStr | Alzheimer’s disease hypothesis and related therapies |
title_full_unstemmed | Alzheimer’s disease hypothesis and related therapies |
title_short | Alzheimer’s disease hypothesis and related therapies |
title_sort | alzheimer’s disease hypothesis and related therapies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789526/ https://www.ncbi.nlm.nih.gov/pubmed/29423193 http://dx.doi.org/10.1186/s40035-018-0107-y |
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