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Alzheimer’s disease hypothesis and related therapies

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, ch...

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Detalles Bibliográficos
Autores principales: Du, Xiaoguang, Wang, Xinyi, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789526/
https://www.ncbi.nlm.nih.gov/pubmed/29423193
http://dx.doi.org/10.1186/s40035-018-0107-y
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author Du, Xiaoguang
Wang, Xinyi
Geng, Meiyu
author_facet Du, Xiaoguang
Wang, Xinyi
Geng, Meiyu
author_sort Du, Xiaoguang
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies.
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spelling pubmed-57895262018-02-08 Alzheimer’s disease hypothesis and related therapies Du, Xiaoguang Wang, Xinyi Geng, Meiyu Transl Neurodegener Review Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies. BioMed Central 2018-01-30 /pmc/articles/PMC5789526/ /pubmed/29423193 http://dx.doi.org/10.1186/s40035-018-0107-y Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Du, Xiaoguang
Wang, Xinyi
Geng, Meiyu
Alzheimer’s disease hypothesis and related therapies
title Alzheimer’s disease hypothesis and related therapies
title_full Alzheimer’s disease hypothesis and related therapies
title_fullStr Alzheimer’s disease hypothesis and related therapies
title_full_unstemmed Alzheimer’s disease hypothesis and related therapies
title_short Alzheimer’s disease hypothesis and related therapies
title_sort alzheimer’s disease hypothesis and related therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789526/
https://www.ncbi.nlm.nih.gov/pubmed/29423193
http://dx.doi.org/10.1186/s40035-018-0107-y
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