What do we measure when we measure cell-associated HIV RNA

Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of...

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Autores principales: Pasternak, Alexander O., Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789533/
https://www.ncbi.nlm.nih.gov/pubmed/29378657
http://dx.doi.org/10.1186/s12977-018-0397-2
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author Pasternak, Alexander O.
Berkhout, Ben
author_facet Pasternak, Alexander O.
Berkhout, Ben
author_sort Pasternak, Alexander O.
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description Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of this biomarker. We discuss a number of important considerations to be taken into account when interpreting CA HIV RNA measurements, as well as different methods to measure this biomarker.
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spelling pubmed-57895332018-02-08 What do we measure when we measure cell-associated HIV RNA Pasternak, Alexander O. Berkhout, Ben Retrovirology Review Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of this biomarker. We discuss a number of important considerations to be taken into account when interpreting CA HIV RNA measurements, as well as different methods to measure this biomarker. BioMed Central 2018-01-29 /pmc/articles/PMC5789533/ /pubmed/29378657 http://dx.doi.org/10.1186/s12977-018-0397-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Pasternak, Alexander O.
Berkhout, Ben
What do we measure when we measure cell-associated HIV RNA
title What do we measure when we measure cell-associated HIV RNA
title_full What do we measure when we measure cell-associated HIV RNA
title_fullStr What do we measure when we measure cell-associated HIV RNA
title_full_unstemmed What do we measure when we measure cell-associated HIV RNA
title_short What do we measure when we measure cell-associated HIV RNA
title_sort what do we measure when we measure cell-associated hiv rna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789533/
https://www.ncbi.nlm.nih.gov/pubmed/29378657
http://dx.doi.org/10.1186/s12977-018-0397-2
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