DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

BACKGROUND: Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson’s disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with major e...

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Detalles Bibliográficos
Autores principales: de Boni, Laura, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789607/
https://www.ncbi.nlm.nih.gov/pubmed/29422978
http://dx.doi.org/10.1186/s13148-018-0440-0

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