Cargando…

Exceptional in vivo catabolism of neurodegeneration-related aggregates

Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a unique phenomenon that Philodina acuticornis, a bdelloid rotifer, is able to catabolize different types of neurotoxic peptide and protein agg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Datki, Zsolt, Olah, Zita, Hortobagyi, Tibor, Macsai, Lilla, Zsuga, Katalin, Fulop, Livia, Bozso, Zsolt, Galik, Bence, Acs, Eva, Foldi, Angela, Szarvas, Amanda, Kalman, Janos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789616/ https://www.ncbi.nlm.nih.gov/pubmed/29378654 http://dx.doi.org/10.1186/s40478-018-0507-3

Ejemplares similares

Neurodegeneration-related beta-amyloid as autocatabolism-attenuator in a micro-in vivo system
por: Balazs, Evelin, et al.
Publicado: (2020)

Application of BisANS fluorescent dye for developing a novel protein assay
por: Datki, Zsolt, et al.
Publicado: (2019)

Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
por: Datki, Zsolt, et al.
Publicado: (2019)

Triterpenes from the Mushroom Hypholoma lateritium: Isolation, Structure Determination and Investigation in Bdelloid Rotifer Assays
por: Chuluunbaatar, Bayar, et al.
Publicado: (2019)

Biological Activities of Four Adaptogenic Plant Extracts and Their Active Substances on a Rotifer Model
por: Mácsai, Lilla, et al.
Publicado: (2018)

Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease
por: Várhelyi, Zoltán P., et al.
Publicado: (2017)

Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers
por: Bartus, Éva, et al.
Publicado: (2018)

Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ (1–42) to the Rat Brain
por: Borbély, Emőke, et al.
Publicado: (2014)

Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration
por: Bencze, János, et al.
Publicado: (2018)

Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis
por: Szabó, Anett, et al.
Publicado: (2023)

ECG alterations suggestive of hyperkalemia in normokalemic versus hyperkalemic patients
por: Varga, Csaba, et al.
Publicado: (2019)

Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors
por: Varga, Edina, et al.
Publicado: (2014)

Antimicrobial Peptide Loss, Except for LL-37, is not Characteristic of Atopic Dermatitis
por: SZABÓ, Lilla, et al.
Publicado: (2023)

Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats
por: Ibos, Katalin Eszter, et al.
Publicado: (2021)

Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target
por: Szögi, Titanilla, et al.
Publicado: (2019)

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ(1–42)-Injected, Wild-Type Mouse Model of AD
por: Borbély, Emőke, et al.
Publicado: (2022)

Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
por: Maasz, Gabor, et al.
Publicado: (2017)

Exercise-related hemoconcentration and hemodilution in hydrated and dehydrated athletes: An observational study of the Hungarian canoeists
por: Komka, Zsolt, et al.
Publicado: (2022)

Integrative profiling of Epstein–Barr virus transcriptome using a multiplatform approach
por: Fülöp, Ádám, et al.
Publicado: (2022)

Acute intracerebral treatment with amyloid-beta (1–42) alters the profile of neuronal oscillations that accompany LTP induction and results in impaired LTP in freely behaving rats
por: Kalweit, Alexander Nikolai, et al.
Publicado: (2015)

Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon
por: Szögi, Titanilla, et al.
Publicado: (2022)

Neoadjuvant cisplatin-based chemotherapy in “primary” and “secondary” muscle-invasive bladder cancer—is it a surrogate for molecular subtypes?
por: Szarvas, Tibor, et al.
Publicado: (2019)

The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration
por: Cervelli, Manuela, et al.
Publicado: (2022)

Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients—a systematic review and meta-analysis
por: Fazekas, Tamás, et al.
Publicado: (2022)

Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory
por: Kasza, Ágnes, et al.
Publicado: (2017)

C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative
por: Fülöp, Zsolt, et al.
Publicado: (2021)

Dialysis patients who smoke are more hypertensive, more fluid overloaded and take more antihypertensive medications than nonsmokers
por: Tapolyai, Mihály, et al.
Publicado: (2020)

Thymic Atrophy and Apoptosis of CD4(+)CD8(+) Thymocytes in the Cuprizone Model of Multiple Sclerosis
por: Solti, Izabella, et al.
Publicado: (2015)

Chronic Effects of Carbamazepine, Progesterone and Their Mixtures at Environmentally Relevant Concentrations on Biochemical Markers of Zebrafish (Danio rerio)
por: Ács, András, et al.
Publicado: (2022)

Ventilator-associated pneumonia and the importance of education of ICU nurses on prevention – Preliminary results
por: Mogyoródi, Bence, et al.
Publicado: (2016)

Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia
por: Bódi, Nikolett, et al.
Publicado: (2021)

GABA(A) receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome
por: Milenkovic, Ivan, et al.
Publicado: (2017)

Metagenomics Reveals Bacterial and Archaeal Adaptation to Urban Land-Use: N Catabolism, Methanogenesis, and Nutrient Acquisition
por: Epp Schmidt, Dietrich J., et al.
Publicado: (2019)

Apocrine Encapsulated Papillary Carcinoma of the Breast: The First Reported Case with an Infiltrative Component
por: Kővári, Bence, et al.
Publicado: (2018)

Involvement of the Catecholamine Pathway in Glioblastoma Development
por: Kraboth, Zoltán, et al.
Publicado: (2021)

Epigenetic Suppression of the IL-7 Pathway in Progressive Glioblastoma
por: Tompa, Marton, et al.
Publicado: (2022)

Draft genome sequence of Methylibium sp. strain T29, a novel fuel oxygenate-degrading bacterial isolate from Hungary
por: Szabó, Zsolt, et al.
Publicado: (2015)

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
por: Oláh, Gáspár, et al.
Publicado: (2013)

Technically Challenging Percutaneous Interventions of Chronic Total Occlusions Are Associated with Enhanced Platelet Activation
por: Illési, Ádám, et al.
Publicado: (2023)

Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species
por: Fodor, István, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mbr6pjlpoqsksjbfrc2c147jta