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Statins decrease leptin expression in human white adipocytes
Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake. Howeve...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789723/ https://www.ncbi.nlm.nih.gov/pubmed/29372612 http://dx.doi.org/10.14814/phy2.13566 |
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author | Singh, Prachi Zhang, Yuebo Sharma, Pragya Covassin, Naima Soucek, Filip Friedman, Paul A. Somers, Virend K. |
author_facet | Singh, Prachi Zhang, Yuebo Sharma, Pragya Covassin, Naima Soucek, Filip Friedman, Paul A. Somers, Virend K. |
author_sort | Singh, Prachi |
collection | PubMed |
description | Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake. However, increases in calorie intake in statin users may also be related to statin‐dependent decreases in satiety factors such as leptin, an adipocyte‐derived adipokine. The objective of our study was to examine the direct effects of statins on leptin expression. Adipocytes are the main source of circulating leptin. Therefore, we examined the effects of atorvastatin and simvastatin on leptin expression in cultured human white adipocytes. We show that treatment of white adipocytes with simvastatin and atorvastatin decreases leptin mRNA expression (simvastatin: P = 0.008, atorvastatin: P = 0.03) and leptin secretion (simvastatin: P = 0.0001, atorvastatin: P = 0.0001). Both simvastatin and atorvastatin mediate decreases in leptin expression via extracellular‐signal‐regulated kinases 1/2 and peroxisome proliferator‐activated receptor gamma pathways (simvastatin: P = 0.01, atorvastatin: P = 0.026). Additionally, statin treatment also induced expected increases in adiponectin, while decreasing monocyte chemoattractant protein 1 (MCP1) mRNA. Furthermore, statins increased secretion of both total as well as high molecular weight adiponectin while decreasing MCP1 secretion. To conclude, statins act directly on human white adipocytes to regulate adipokine secretion and decrease leptin expression. Leptin is an important satiety factor. Hence, statin‐dependent decreases in leptin may contribute, at least in part, to increases in food intake in statin users. |
format | Online Article Text |
id | pubmed-5789723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57897232018-02-08 Statins decrease leptin expression in human white adipocytes Singh, Prachi Zhang, Yuebo Sharma, Pragya Covassin, Naima Soucek, Filip Friedman, Paul A. Somers, Virend K. Physiol Rep Original Research Statin use is associated with increased calorie intake and consequent weight gain. It is speculated that statin‐dependent improvements in lipid profile may undermine the perceived need to follow lipid‐lowering and other dietary recommendations leading consequently to increased calorie intake. However, increases in calorie intake in statin users may also be related to statin‐dependent decreases in satiety factors such as leptin, an adipocyte‐derived adipokine. The objective of our study was to examine the direct effects of statins on leptin expression. Adipocytes are the main source of circulating leptin. Therefore, we examined the effects of atorvastatin and simvastatin on leptin expression in cultured human white adipocytes. We show that treatment of white adipocytes with simvastatin and atorvastatin decreases leptin mRNA expression (simvastatin: P = 0.008, atorvastatin: P = 0.03) and leptin secretion (simvastatin: P = 0.0001, atorvastatin: P = 0.0001). Both simvastatin and atorvastatin mediate decreases in leptin expression via extracellular‐signal‐regulated kinases 1/2 and peroxisome proliferator‐activated receptor gamma pathways (simvastatin: P = 0.01, atorvastatin: P = 0.026). Additionally, statin treatment also induced expected increases in adiponectin, while decreasing monocyte chemoattractant protein 1 (MCP1) mRNA. Furthermore, statins increased secretion of both total as well as high molecular weight adiponectin while decreasing MCP1 secretion. To conclude, statins act directly on human white adipocytes to regulate adipokine secretion and decrease leptin expression. Leptin is an important satiety factor. Hence, statin‐dependent decreases in leptin may contribute, at least in part, to increases in food intake in statin users. John Wiley and Sons Inc. 2018-01-26 /pmc/articles/PMC5789723/ /pubmed/29372612 http://dx.doi.org/10.14814/phy2.13566 Text en © 2018 Mayo Foundation For Medical Education And Research. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Singh, Prachi Zhang, Yuebo Sharma, Pragya Covassin, Naima Soucek, Filip Friedman, Paul A. Somers, Virend K. Statins decrease leptin expression in human white adipocytes |
title | Statins decrease leptin expression in human white adipocytes |
title_full | Statins decrease leptin expression in human white adipocytes |
title_fullStr | Statins decrease leptin expression in human white adipocytes |
title_full_unstemmed | Statins decrease leptin expression in human white adipocytes |
title_short | Statins decrease leptin expression in human white adipocytes |
title_sort | statins decrease leptin expression in human white adipocytes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789723/ https://www.ncbi.nlm.nih.gov/pubmed/29372612 http://dx.doi.org/10.14814/phy2.13566 |
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