N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells

Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by...

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Detalles Bibliográficos
Autores principales: Sun, Ting, Zhang, Yanmei, Zhong, Shuping, Gao, Fenfei, Chen, Yicun, Wang, Bin, Cai, Wenfeng, Zhang, Zhaojing, Li, Weiqiu, Lu, Shishi, Zheng, Fuchun, Shi, Ganggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789774/
https://www.ncbi.nlm.nih.gov/pubmed/29422863
http://dx.doi.org/10.3389/fphar.2018.00019

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