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Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Mutations in the progranulin (PGRN) gene cause a tau pathology-negative and TDP43 pathology-positive form of frontotemporal lobar degeneration (FTLD-TDP). We generated a knock-in mouse harboring the R504X mutation (PGRN-KI). Phosphoproteomic analysis of this model revealed activation of signaling pa...

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Detalles Bibliográficos
Autores principales:	Fujita, Kyota, Chen, Xigui, Homma, Hidenori, Tagawa, Kazuhiko, Amano, Mutsuki, Saito, Ayumu, Imoto, Seiya, Akatsu, Hiroyasu, Hashizume, Yoshio, Kaibuchi, Kozo, Miyano, Satoru, Okazawa, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789822/ https://www.ncbi.nlm.nih.gov/pubmed/29382817 http://dx.doi.org/10.1038/s41467-018-02821-z

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