Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Many ion channels, including Nav1.7, Cav1.3, and Kv1.3, are linked to human pathologies and are important therapeutic targets. To develop efficacious and safe drugs, subtype-selective modulation is essential, but has been extremely difficult to achieve. We postulate that this challenge is caused by...

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Detalles Bibliográficos
Autores principales: Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789920/
https://www.ncbi.nlm.nih.gov/pubmed/29311306
http://dx.doi.org/10.1073/pnas.1713701115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789920/
https://www.ncbi.nlm.nih.gov/pubmed/29311306
http://dx.doi.org/10.1073/pnas.1713701115

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