RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a key player driving the early specification of cell fate. RASSF1A acts as a natural barrier to stem cell self-renewal and iPS cell generation, b...

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Detalles Bibliográficos
Autores principales: Papaspyropoulos, Angelos, Bradley, Leanne, Thapa, Asmita, Leung, Chuen Yan, Toskas, Konstantinos, Koennig, Delia, Pefani, Dafni-Eleftheria, Raso, Cinzia, Grou, Claudia, Hamilton, Garth, Vlahov, Nikola, Grawenda, Anna, Haider, Syed, Chauhan, Jagat, Buti, Ludovico, Kanapin, Alexander, Lu, Xin, Buffa, Francesca, Dianov, Grigory, von Kriegsheim, Alex, Matallanas, David, Samsonova, Anastasia, Zernicka-Goetz, Magdalena, O’Neill, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789973/
https://www.ncbi.nlm.nih.gov/pubmed/29382819
http://dx.doi.org/10.1038/s41467-017-02786-5

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