Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database

Computational inference of mutation effects is necessary for genetic studies in which many mutations must be considered as etiologic candidates. Programs such as PolyPhen-2 predict the relative severity of damage caused by missense mutations, but not the actual probability that a mutation will reduc...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Bu, Chun Hui, Hildebrand, Sara, Jia, Gaoxiang, Siggs, Owen M., Lyon, Stephen, Pratt, David, Scott, Lindsay, Russell, Jamie, Ludwig, Sara, Murray, Anne R., Moresco, Eva Marie Y., Beutler, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789985/
https://www.ncbi.nlm.nih.gov/pubmed/29382827
http://dx.doi.org/10.1038/s41467-017-02806-4

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