Activated CD8(+) T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

Fibroblastic tumour stroma comprising mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promotes the invasive and metastatic properties of tumour cells. Here we show that activated CD8(+) T cell-derived extracellular vesicles (EVs) interrupt fibroblastic stroma-mediated tumour p...

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Detalles Bibliográficos
Autores principales: Seo, Naohiro, Shirakura, Yoshitaka, Tahara, Yoshiro, Momose, Fumiyasu, Harada, Naozumi, Ikeda, Hiroaki, Akiyoshi, Kazunari, Shiku, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789986/
https://www.ncbi.nlm.nih.gov/pubmed/29382847
http://dx.doi.org/10.1038/s41467-018-02865-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789986/
https://www.ncbi.nlm.nih.gov/pubmed/29382847
http://dx.doi.org/10.1038/s41467-018-02865-1

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